pain models for neuropathic, nociceptive, inflammatory and post-operative pain

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Preclinical efficacy testing in models of pain

Acute or nociceptive pain is part of a rapid warning relay instructing the motor neurons of the central nervous system to minimize detected physical harm. Chronic pain, however, serves no biological function as it is not a symptom of a disease process itself but is classified as a disease. Chronic pain encompasses neuropathic pain, pain produced by damage to the neruons in the peripheral and central nervous system, and inflammatory pain. One of the challenges for researchers and clinicians alike is that chronic pain my involve a mix of both inflammatory and neuropathic components, wheras inflammation may cause damage to the neurons and produce neuropathic pain or neuronal injury may cause an inflammatory reaction that contributes to the inflammatory pain.

MD Biosciences offers a wide range of pre-clinical contract research models that can be customized according to sponsors criteria.

Nociceptive Pain Preclinical Research Models
Inducer Species Mediating Factors
Caspaicin mouse, rat VR1
Tail Flick mouse, rat external stimuli
Visceral mouse Acid

 

Inflammatory and Arthritic Pain Preclinical Research Models
Inducer Species Mediating Factors
Carrageenan rat PGE2 and mast cells
CFA (poly-RA)
 rat Cytokines, PG, macrophages, Neutrophils
CFA (mono-RA) mouse, rat Cytokines, PG, macrophages, Neutrophils
Collagen (RA) rat Cytokines, macrophages, Neutrophils
Adjuvant (RA) rat Cytokines, PG, macrophages, Neutrophils

 

Neuropathic Pain Preclinical Research Models
Inducer Species Mediating Factors
Surgery of sciatic nerve (CCI) whitepaper
 rat inflammation of the nerve
Surgery of the sciatic nerve, cutting (SNL) whitepaper mouse, rat damage to the nerve
STZ (diabetic) rat damage to the nerve ending due to hyperglycemia and hypoxia
Taxol rat taxol-mediated neurotoxicity by interfering with sensory neuron skeleton structure

 

Post-operative (incisional) Pain Preclinical Research Models
Inducer Species Mediating Factors
Incision (Brennan) rat inflammation, wound
Incision whitepaper
 piglet inflammation, wound

 

eBook: Pain Processing and Pathways. Choosing suitable behavior tests for common drug classes based on mechanisms and site of action.

Pain Processing and Pathways

  • Cannabinoid Receptor Agonists
  • FAAH Inhibition
  • Opioids
  • alpha2-adrenergic agonists
  • tricyclic anti-depressants
  • NSAIDs
  • Cation channel blockers (Na+, Ca+, TRPV1)

 

Download Pain Processing and Pathways eBook

 



Interesting Fact

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