Acute or nociceptive pain is part of a rapid warning relay instructing the motor neurons of the central nervous system to minimize detected physical harm. Chronic pain, however, serves no biological function as it is not a symptom of a disease process itself but is classified as a disease. Chronic pain encompasses neuropathic pain, pain produced by damage to the neruons in the peripheral and central nervous system, and inflammatory pain. One of the challenges for researchers and clinicians alike is that chronic pain my involve a mix of both inflammatory and neuropathic components, whereas inflammation may cause damage to the neurons and produce neuropathic pain or neuronal injury may cause an inflammatory reaction that contributes to the inflammatory pain.
MD Biosciences offers a wide range of pre-clinical contract research models that can be customized according to sponsors criteria.
Nociceptive Pain Preclinical Research Models
- Caspaicin
- Reflect Pathway, Flick
- Visceral
Inflammatory and Arthritic Pain Preclinical Research Models
- Carrageenan
- CFA (mono or poly RA)
- Collagen RA
- Adjuvant RA
Neuropathic Pain Preclinical Research Models
- Chronic Constriction (CCI)
- Chung model
- STZ diabetic
- Taxol
Post-operative Pain Preclinical Research Models
- Brennan POP model
- Flank POP model