MD Biosciences offers several models of inflammatory and arthritic pain. Models of inflammatory pain are appropriate for evaluating the following drug classes:
- Cannabinoid Receptor Agonists
- FAAH Inhibition
- apha2-adrenergic agonists
- NSAIDs
- opioids
- TRPV1
- Sodium Channel Blockers
| General Inflammatory Pain Preclinical Research Models Request Proposal |
| Model |
CFA |
Carrageenan |
| Length |
24 hours |
3 hours |
| Positive Control |
Diclofenac |
Diclofenac |
| Measurements |
Body weight
Clinical signs
Mechanical Allodynia
Thermal Hyperalgesia
Paw volume |
Body weight
Clinical signs
Mechanical Allodynia
Thermal Hyperalgesia
Paw volume |
| Add-ons |
Blood samples |
Blood samples |
| Arthritic Pain Preclinical Research Models Request Proposal |
| Model |
Adjuvant-induced Polyarthritic Pain |
Adjuvant-induced Monoarthritic Pain |
MIA Osteoarthritic Pain |
| Length |
28 days |
28 days |
15-35 days |
| Positive Control |
Morphine |
Morphine |
Morphine
Diclofenac |
| Measurements |
Arthritis score
Clinical signs
Body weight
Mechanical Allodynia
Thermal Hyperalgesia |
Body weight
Clinical signs
Weight bearing
Mechanical Allodynia
Thermal Hyperalgesia |
Body weight
Clinical signs
Weight bearing
Motor function test |
| Add-ons |
Paw Volume
Histology
Cytokine Analysis
Gene Expression |
Paw Volume
Histology
Cytokine Analysis
Gene Expression |
Histology
Cytokine Analysis
Gene Expression |