Neuropathic Pain is produced by damage to the neurons in the peripheral and central nervous systems and involves sensitization of these systems. In peripheral sensitization, there is an increase in the stimulation of peripheral nociceptors that amplifies pain signals to the central nervous system (CNS). In central sensitization, neurons that originate in the dorsal horn of the spinal cord become hyperstimulated, increasing pain signals to the brain and thereby increasing pain sensation. It is most commonly associated with chronic allodynia and hyperalgesia.
MD Biosciences offers a wide range of pre-clinical pain models for neuropathic pain that can be customized according to sponsors criteria:
- Spinal Nerve Ligation (SNL), also known as the Chung model. Peripheral neuropathic pain model.
- Chronic Constriction Injury (CCI), also known as the Bennett and Xie. Peripheral neuropathic pain model.
- STZ-induced diabetic neuropathy.
- Taxol-induced peripheral neuropathy. A chemotherapy-inuduced pain model
- Vincristine-induced peripheral neuropathy. A chemotherapy-incuded pain model.
Models of Neuropathic pain are appropriate for evaluating the following drug classes:
- Cannabinoid Receptor Agonists
- FAAH Inhibition
- apha2-adrenergic agonists
- tricylic anti-depressants
- opioids
- TRPV1
- Sodium and calcium Channel Blockers