Neuropathic Pain is produced by damage to the neurons in the peripheral and central nervous systems and involves sensitization of these systems. In peripheral sensitization, there is an increase in the stimulation of peripheral nociceptors that amplifies pain signals to the central nervous system (CNS). In central sensitization, neurons that originate in the dorsal horn of the spinal cord become hyperstimulated, increasing pain signals to the brain and thereby increasing pain sensation. It is most commonly associated with chronic allodynia and hyperalgesia.
MD Biosciences offers a wide range of pre-clinical pain models for neuropathic pain that can be customized according to sponsors criteria. Models of Neuropathic pain are appropriate for evaluating the following drug classes:
- Cannabinoid Receptor Agonists
- FAAH Inhibition
- apha2-adrenergic agonists
- tricylic anti-depressants
- opioids
- TRPV1
- Sodium and calcium Channel Blockers
| Neuropathic Pain Preclinical Research Models Request Proposal |
| Model |
CCI Chronic Constriction Injury (Bennett & Xie)* |
Spinal Nerve Ligation (Chung)* |
Taxol |
STZ Diabetic Neuropathy |
| Length |
14 days |
14-28 days |
15 days |
20 days |
| Positive Control |
Morphine
Gabapentin |
Morphine
Gabapentin |
Morphine |
Morphine
Gabapentin |
| Measurements |
Body weight
Clinical signs
Mechanical Allodynia |
Body weight
Clinical signs
Mechanical Allodynia |
Body weight
Clinical signs
Mechanical Allodynia
Thermal Hyperalgesia
|
Blood Glucose
Body weight
Clinical signs
Mechanical Allodynia |
| Add-ons |
Blood samples, histology |
Blood samples, histology |
Blood samples |
Blood samples, histology |
*Whitepaper: Peripheral Nerve Injury Models of Neuropathic Pain. Understanding the mechanisms underlying Neuropathic pain syndroms is crucial to the development of more effective therapies.