Neuropathic pain is produced by damage to the neurons in the peripheral and central nervous systems and involves sensitization of these systems. In peripheral sensitization, there is an increase in the stimulation of peripheral nociceptors that amplifies pain signals to the central nervous system (CNS). In central sensitization, neurons that originate in the dorsal horn of the spinal cord become hyperstimulated, increasing pain signals to the brain and thereby increasing pain sensation. It is most commonly associated with chronic allodynia and hyperalgesia.
While rodent models of neuropathic pain have provided value in the research community, it is also known that the need for more translational models is high. MD Biosciences offers neuropathic pain models in both the rodent as well as the pig bringing much needed translational value from preclinical studies to the human situation. Speak to a scientist to determine which neuropathic pain model is most relevant to your program.
Our electrophysiology laboratory capabilities are suited to record and analyze CNS pain and peripheral pain. Learn more about these capabilities here.
|Pain Tests:||Dosing Routes:|
|Paw Pressure||Injection (IP, SC, dermal)|
|Weight Bearing||Infusion Pump|
|Local/Direct to nerve|