Nociceptors are specialized sensory neurons that preferentially respond to noxious stimuli. Nociceptive or physiological pain refers to the type of pain that we feel on a day-to-day basis. It is directly associated with a noxious stimulus, such as bending our joints too far, and helps us put limits on ourselves to avoid damage. This information is mediated by both small unmyelinated fibers and myelinated fibers, and provides us with an awareness of the environment. Nociceptive pain is pharmacologically treatable.
MD Biosciences offers a wide range of pre-clinical pain models for nociception that can be customized according to sponsors criteria. Don't see the model or assessment you require? Our scientists are experienced with rapidly validating models from the literature. Please speak with a scientist to discuss your requirements.
The time it takes for the animal to flick its tail is recorded. The tail flick test is performed at appropriate time points following treatment.