Nociception | Preclinical Pain Models

Nociceptors are specialized sensory neurons that preferentially respond to noxious stimuli. Nociceptive or physiological pain refers to the type of pain that we feel on a day-to-day basis. It is directly associated with a noxious stimulus, such as bending our joints too far, and helps us put limits on ourselves to avoid damage. This information is mediated by both small unmyelinated fibers and myelinated fibers, and provides us with an awareness of the environment. Nociceptive pain is pharmacologically treatable.

MD Biosciences offers a wide range of pre-clinical pain models for nociception that can be customized according to sponsors criteria. Models of Nociception are appropriate for evaluating the following drug classes:

• Cannabinoid Receptor Agonists
• FAAH Inhibition
• apha2-adrenergic agonists 
• opioids
• TRPV1
• Sodium Channel Blockers