preclinical CRO, pain models, neuropathic pain

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Post-operative (Incisional) Pain

The under treatment of post-operative (incisional) pain has been recognized to delay patient recovery and discharge from hospital. Despite recognition of the importance of effective pain control, up to 70% of patients still complain of moderate to severe pain post operatively. The most commonly used model to test the effect of new analgesic drugs in post-operative (incisional) pain is the Brennan model. Although, this model can provide good answers to systemic drugs it is less suitable for testing local treatments such as implants, patches, medical devices and creams.

MD Biosciences has developed a unique post-operative (incisional) model to meet this growing need and allows for the assessment of local and systemic therapies. Models of Post operative (incisional) pain are appropriate for evaluating implants, patches, medical devices and creams.

MD Biosciences offers both the rodent and a porcine model of POP. The porcine POP provides greater translational relevance for the evaluation of topical and local treatments. We have published the characterization of the model in the Eur J Pain (European Journal of Pain, Sept 2013, Characterization of a porcine model of post-operative pain, Dr Sigal Meilin, MD Biosciences)

Post Operative (Incisional) Pain Preclinical Research Models    Request Proposal
Model Brennan Post-operative Pain in rats Porcine Post-operative Pain with Von Frey*
Length 3-6 days up to 14 days
Positive Control Morphine Morphine
Measurements Body weight
Clinical signs
Mechanical Allodynia
Body weight
Clinical signs
Mechanical Allodynia
Add-ons Blood samples Blood samples, histology

*Whitepaper: A new model of post-operative pain. An optimal model for assesssment of analgesic effect of various local treatment strategies such as new implants, patches, medical devices and creams.