Peripheral Nerve Injury (PNI) Models of Neuropathic Pain
Neuropathic pain may arise from many different disease states and present with a variety of symptoms, including shooting or burning pain, tingling, numbness, and allodynia (pain in response to a normally innocuous stimulus). Clinically significant relief is often difficult to achieve, in part because conventional opioid therapy is typically less effective for neuropathic pain. Also, patients vary widely in their response to other types of analgesics. Understanding the mechanisms and underlying neuropathic pain syndromes is crucial to the development of more effective therapies.
At MD Biosciences we commonly use the rat and mouse sciatic nerve crush model to assess post-traumatic nerve regeneration. The animals do experience pain, but have no motor disturbances.
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Von Frey measurements in the mouse sciatic nerve crush model of peripheral nerve injury (PNI).