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Preclinical Pharmacology & Efficacy

Rat Sciatic Nerve Crush Model

Peripheral Nerve Injury (PNI) Models of Neuropathic Pain

Sciatic nerve injury model for assessment of nerve regeneration following PNI

Neuropathic pain may arise from many different disease states and present with a variety of symptoms, including shooting or burning pain, tingling, numbness, and allodynia (pain in response to a normally innocuous stimulus). Clinically significant relief is often difficult to achieve, in part because conventional opioid therapy is typically less effective for neuropathic pain. Also, patients vary widely in their response to other types of analgesics. Understanding the mechanisms and underlying neuropathic pain syndromes is crucial to the development of more effective therapies.


At MD Biosciences we commonly use the rat and mouse sciatic nerve crush model to assess post-traumatic nerve regeneration. The animals do experience pain, but have no motor disturbances. 


Model Specifications
  • Model length - up to 31 days
  • Positive controls: morphine, gabapentin, pregabalin
  • Readouts: tactile allodynia (Von Frey), cold allodynia
  • Endpoints: histology, biomarker analysis (protein or mRNA levels in sciatic nerve or serum/plasma)


Don't see the model or assessment you require? Our scientists are experienced with rapidly validating models from the literature. Please speak with a scientist to discuss your requirements. 


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clinically relevant model of neuropathic pain





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