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Preclinical Pharmacology & Efficacy

Mouse Sciatic Nerve Cuff

Peripheral Nerve Injury (PNI) Models of Neuropathic Pain

Sciatic nerve cuff model of peripheral neuropathic pain.

The mouse nerve cuff model is based on a compression of the sciatic nerve using a polyethylene cuff that is implanted around the main branch of the sciatic nerve. It produces a more consistent pain with less variability than other mouse models of peripheral nerve injury (PNI).  


Model Specifications
  • Model length - up to 30 days
  • Positive controls: morphine, gabapentin, pregabalin
  • Readouts*: tactile allodynia (Von Frey), cold allodynia
  • Endpoints: histology, biomarker analysis (protein or mRNA levels in sciatic nerve or serum/plasma)


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clinically relevant model of neuropathic pain





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