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Preclinical Laboratory Services

Mouse Sciatic Nerve Cuff

Peripheral Nerve Injury (PNI) Models of Neuropathic Pain

Sciatic Nerve Cuff Model of Peripheral Neuropathic Pain

The mouse nerve cuff model is based on a compression of the sciatic nerve using a polyethylene cuff that is implanted around the main branch of the sciatic nerve. It produces a more consistent pain with less variability than other mouse models of peripheral nerve injury (PNI).  

 Model Specifications

  • Model length - up to 30 days
  • Positive controls: morphine, gabapentin, pregabalin
  • Readouts*: tactile allodynia (Von Frey), cold allodynia
  • Endpoints: histology, biomarker analysis (protein or mRNA levels in sciatic nerve or serum/plasma)

Don't see the model or assessment you require? Our scientists are experienced with rapidly validating models from the literature. Please speak with a scientist to discuss your requirements. 

 

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clinically relevant model of neuropathic pain

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