Preclinical Pharmacology & Efficacy

Neuropathic Pain Models

Rodent and swine models for nerve injury studies.

Peripheral Nerve Injury (PNI) models of neuropathic pain

Neuropathic pain may arise from many different disease states and present dwith a variety of symptoms, including shooting or burning pain, tingling, numbness, and allodynia (pain in response to a normally innocuous stimulus). Clinically significant relief is often difficult to achieve, in part because conventional opioid therapy is typically less effective for neuropathic pain. Also, patients vary widely in their response to other types of analgesics. Understanding the mechanisms underlying neuropathic pain syndromes is crucial to the development of more effective therapies.

 

MD Biosciences offers several well- established peripheral nerve injury models of neuropathic pain: spinal nerve ligation (SNL), chronic constriction injury (CCI), mouse sciatic nerve cuff and rat sciatic nerve crush. Additionally, we have validated a large animal model of sciatic nerve injury as a clinically relevant translational model. 

 

Speak to a scientist to discuss which model is most suitable for your program.
 

 

Model Specifications
  • Model length - up to 42 days
  • Positive controls: morphine, gabapentin, pregabaline
  • Readouts*: tactile allodynia (von Frey), cold allodynia
  • Endpoints: histology, biomarker analysis (protein or mRNA levels in sciatic nerve or serum/plasma)

 

Don't see the model or assessment you require? Our scientists are experienced with rapidly validating models from the literature. Please speak with a scientist to discuss your requirements. 

 

 

Request Study Proposal

 

clinically relevant model of neuropathic pain

 


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