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Neurology Disease Models

Parkinson's Disease Models

Parkinon's Disease (PD) is a neurogenerative disorder characterized by reduction in striatial (DA) content caused by the loss of dopaminergenic neurons in the Substantia Nigra part compacta (SNpc) and their proportions to the striatum. Several neurotoxins induced PD-like neuropathology in animals, includeing the neurotoxins 6-hydroxydopamine (6OHDA) and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). These models mimic the depletion in dopaminergic (DAmergic) cells.

MD Biosciences Parkinson's Disease In-vivo Models

 Type Model  Description
 In Vivo Acute MPTP model  

This model is an acute histology-based model mimicking the depletion of 50-60% in Tyrosine-hydroxilase (TH) immunoreactive cells at the level of the Substantia Nigra pars compacta without affecting the general motor activity of the animals.

 
       

 In Vivo

 Chronic MPTP model  

This model combines the depletion in the TH-immunoreactive cells with a decrease in motor activity as observed in animals treated with  MPTP vs saline. We are able to monitor motor function depletion in addition to the histological assessment of DAmergic neuron depletion.

   
       

 In Vivo

 6OHDA-induced model.  

This model is a unilateral lesion model of which the Nigro-Striatal pathway is damaged. The unilateral dopamine denercation induces a number of behavorial deficits similar to those observed in patients with PD and a variety of tests are used to evaluate spontanteous and drug-induced behavioral changes.

 
       

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Custom designed models and in vitro assays available. Please contact a representative to discuss a custom assay design.