The under treatment of post-operative (incisional) pain has been recognized to delay patient recovery and discharge from hospital. Despite recognition of the importance of effective pain control, up to 70% of patients still complain of moderate to severe pain post operatively. The most commonly used model to test the effect of new analgesic drugs in post-operative (incisional) pain is the Brennan model in rats. Although, this model can provide good answers to systemic drugs it is less suitable for testing local treatments such as implants, patches, medical devices and creams.
MD Biosciences has developed a unique post-operative (incisional) model in pigs to meet this growing need and allows for the assessment of local and systemic therapies. Models of Post operative (incisional) pain are appropriate for evaluating implants, patches, medical devices and creams and the following drug classes:
- Cannabinoid Receptor Agonists
- FAAH Inhibition
- apha2-adrenergic agonists
- tricylic anti-depressants
- NSAIDs
- opioids
- TRPV1
- Sodium Channel Blockers
Post Operative (Incisional) Pain Preclinical Research Models Request Proposal
|
| Model |
Post-operative Pain (Brennan)
|
Post-operative Pain*
|
| Strain |
SD rats |
Domestic piglets
|
| Length |
3-6 days |
up to 16 days |
| Positive Control |
Morphine |
Morphine |
| Measurements |
Body weight
Clinical signs
Mechanical Allodynia |
Body weight
Clinical signs
Mechanical Allodynia |
| Add-ons |
Blood samples |
Blood samples, histology |
*Whitepaper: A new animal model of post-operative pain. An optimal model for assesssment of analgesic effect of various local treatment strategies such as new implants, patches, medical devices and creams.