Preclinical Research

Dermal Inflammation

Dermatological Modeling of Inflammatory and Autoimmune Conditions

 

Dermal Pharmacology and Efficacy Studies 

MD Biosciences laboratories specialize in dermal research with a host of preclinical and translational models. Imiquimod and IL-23 induced psoriasis, FITC or DNCB induced dermatitis, oxazolone induced, delayed type hypersensitivity, as well as passive cutaneous anaphylaxis form the stable of validated models offered by MD Biosciences. Models are supported by a range of read-outs including protein and mRNA, histology and flow cytometry.

Our preclinical rodent models are complimented by our translational disease models in the pig, benefitting from the considerable similarities between the skin structure of the pig and humans with respect to vascularization, innervation and structure.  These similarities make the pig skin ideal for studying wound healing as well.

Are you searching for a new model or one not listed below? We would be happy to discuss validating and piloting new models. Contact us today to discuss your study needs. 
 

Experience Readouts Options
Biologics Psoriasis score Biomarkers (protein, mRNA)
NCEs Ear thickness Cell populations by FACS
Plant-based compounds Body Weights Histology/IHC
   Wound healing PK

Contact a scientist
 to discuss one of our preclinical models and/or efficacy studies for dermal conditions.

 

 

Request Study Proposal

 


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