Dermatological Modeling of Inflammatory and Autoimmune Conditions
MD Biosciences laboratories specialize in dermal research with a host of preclinical and translational models. Imiquimod and IL-23 induced psoriasis, FITC or DNCB induced dermatitis, oxazolone induced, delayed type hypersensitivity, as well as passive cutaneous anaphylaxis form the stable of validated models offered by MD Biosciences. Models are supported by a range of read-outs including protein and mRNA, histology and flow cytometry.
Our preclinical rodent models are complimented by our translational disease models in the pig, benefitting from the considerable similarities between the skin structure of the pig and humans with respect to vascularization, innervation and structure. These similarities make the pig skin ideal for studying wound healing as well.
Are you searching for a new model or one not listed below? We would be happy to discuss validating and piloting new models. Contact us today to discuss your study needs.
|Biologics||Psoriasis score||Biomarkers (protein, mRNA)|
|NCEs||Ear thickness||Cell populations by FACS|
|Plant-based compounds||Body Weights||Histology/IHC|