Publications & Abstracts

Preclinical efficacy disease models: development & compound evaluation

CRO Publications by MD Biosciences

 

 

POP model: Castel, D., Willentz, E., Doron, O., Brenner, O. and Meilin, S. (2014), Characterization of a porcine model of post-operative pain. European Journal of Pain, 18: 496–505. doi: 10.1002/j.1532-2149.2013.00399.x

 

4VO model: Meilin, S., Machicao, F., & Elmlinger, M. (2014). Treatment with Actovegin improves spatial learning and memory in rats following transient forebrain ischaemia. Journal of Cellular and Molecular Medicine (8), 1623–1630. doi:10.1111/jcmm.12297

 

 

Abstracts & Citations


CIA model: Chondroprotective activity of acti-joint®, a combination of chondroitin sulfate, glucosamine and a natural ingredient rich in hyaluronic acid. A. Torrent, E. Montell, J. Vergés, R. Ruhí, S. Meilin, H. Sonego, P. Mainil-Varlet. Osteoarthritis and Cartilage, Volume 22, S324 - S325

 

4VO model: Practical Applications of in Vivo and ex Vivo MRI in Toxicologic Pathology Using a Novel High-performance Compact MRI System. Tempel-Brami C, Schiffenbauer YS, Nyska A, Ezov N, Spector, Abramovitch R, Maronpot RR. Toxicol Pathol. 2015 Feb 18. pii: 0192623314568390

 

TNBS model: J. T. Dudley, M. Sirota, M. Shenoy, R. K. Pai, S. Roedder, A. P. Chiang, A. A. Morgan, M. M. Sarwal, P. J. Pasricha, A. J. Butte, Computational Repositioning of the Anticonvulsant Topiramate for Inflammatory Bowel Disease. Sci. Transl. Med. Sci. Transl. Med. 3, 96ra76 (2011)

 

CIA model: Supplementation of diet with krill oil protects against experimental rheumatoid arthritis. M Ierna, A Kerr, H Scales, K Berge, and M Griinari BMC Musculoskelet Disord, Jan 2010; 11: 136.

 

IMQ model: Identi­cation of Highly Potent and Selective Interleukin-1 Receptor-Associated Kinase 4 Inhibitors for the Treatment of Rheumatic Diseases

 

 

     


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