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Cerebral Ischemia models

Assessing neuroprotective therapies.

Focal and Global Cerebral Ischemia models for evaluation of cognition, motor function and neuroprotection.

Cerebral ischemia has a complex pathophysiology involving the interplay of many different cells and tissues such as neurons, glia, endothelium and the immune system. There are a number of preclinical models of ischemia that can be used to study the patholohysiology of cerebral ischemic insults. These models primarily involve interference with blood supply to the brain and are divided into focal (stroke) and global (caridac arrest). Additionally, the occlusion can be permanent or transient giving either an ischemic insult or a reperfusion injury. With each model and variation, different areas of the brain are impacted resulting in different behavioral outcomes.  


This data pack reviews the following:

  • Different models of cerebral ischemia and the behavioral outcomes resulting in each
  • Tests for sensory-motor function
  • Tests for spatial memory and learning
  • Histological assessment of infarct volume