The collagen induced arthritis (CIA) model has become the 'gold standard' in preclinical rheumatology research over the past three decades. The reasons for this are the reproducibility of disease and the similarity in proposed mechanism of disease induction compared to the human condition, such as:
humoral and cellular responses to type II collagen
genetic predisposition to MHC Class II
peripheral diathroidal joints involved, often symmetrically
pannus formation including inflammatory cell infiltration
cartilage and bone erosion
fibrin, Ig and complement deposition
The incidence of disease in the CIA study is often affected by the induction reagents used. MD Biosciences has more than 10 years experience with the CIA model in both mouse and rats and has optimized the induction system for optimal model performance.