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Collagen-induced Arthritis

 Data from mouse and rat CIA models

Collagen Induced Arthritis in Rodents

The collagen induced arthritis (CIA) model has become the 'gold standard' in preclinical rheumatology research over the past three decades. The reasons for this are the reproducibility of disease and the similarity in proposed mechanism of disease induction compared to the human condition, such as:
  • humoral and cellular responses to type II collagen
  • genetic predisposition to MHC Class II
  • peripheral diathroidal joints involved, often symmetrically
  • pannus formation including inflammatory cell infiltration
  • cartilage and bone erosion
  • fibrin, Ig and complement deposition
  • metalloproteinase involvement
The incidence of disease in the CIA study is often affected by the induction reagents used. MD Biosciences has more than 10 years experience with the CIA model in both mouse and rats and has optimized the induction system for optimal model performance.