Monosodium iodoacetate (MIA) induced osteoarthritis Efficacy Data Sheet
The MIA-induced OA model in rats is induced with a monosodium iodoacetate (MIA) injection in the space between the tibia and femur in the flexed right knee joint. This chemical insult intiates an inflammatory reaction involving inflammatory mediators such as TNF-a, IL-1b, IL-6 and NGF. Cartilage damage and degradation leads to a chronic neuronal damage with neuropathic charac- teristics. Supportive evidence of this is the fact that CGRP is massively elevated in the sensory neurons innervating the knee and the DGR. CGRP is an inflammatory driven neuronal marker and its expression depends on NGF expression.