The administration of MOG creates an encephalitogenic T-cell response and a demyelinating autoantibody response in certain mouse strains. The MOG 35-55 peptide in combination with pertussis toxin (PT) injections, which increases the permability of the BBB, is used for disease induction in C57Bl/6 animals. The resulting disease is a chronic-progressive form of encephalomyelitis (EAE), which is characterized by axonal demyelination and white matter lesions in the spinal cord.
The following data pack shows
clinical score data
motor function and the correlation to clinical score
H&E staining to assess cell infiltration and white matter density