Clinically translational model of neuropathic pain
Nerve injury in the peripheral or central nervous system can result from various insults including trauma or inflammatory/immune-mediated responses. Animal models are pivatol for understanding mechanisms that may contribute to human neuropathic pain and development of effective therapies. While rodent models of nerve injury are commonly used, there is a gap between translating the data from preclinical to clinical stages. We have developed a large animal or neuropathic pain that correlates to the clinic and provides drug developers with a useful tool.
Covered in this Datasheet:
Advantages of the pig as a model system
Overview of surgical procedure
Von Frey data
Spontaneous behavior Score
Motor function parameters
Positive controls including Aprepitant, which showed efficacy in rodent studies but failed in clinical trials.