Webinar:

A clinically relevant, large animal

model of Peripheral Neuropathy

 

Can we increase the preclinical validity in pain research?

Animal models are pivotal for understanding mechanisms that may contribute to human neuropathic pain and development of effective therapy. For reasons of reproducibility and simplicity, rodent models of traumatic nerve injury are commonly used for research. Over the last few decades, these rodent models have led to a substantial increase in the knowledge of pain mechanisms but new drugs showing promise in preclinical models have often failed clinical trials due to lack of efficacy or unpredicted adverse effects in humans. Given this lack of predictability of animal models, we began to rethink what can be done to increase preclinical validity in pain research. Over the past year, we have developed a large animal translational model for trauma induced peripheral neuropathy. 

 

Topics in the webinar:

  • Characterization of three different peripheral nerve injuries, the benefits and limitations of each.
  • The pig as a relevant and translational model for human chronic pain conditions.
  • A look at subjective/spontaneous pain behavior and motor function as a result of each peripheral nerve injury.
  • Mechanical (Von Frey) and Tactile (feather test) assessments which are both used in the clinic to calibrate and deterine the level of neuropathic pain in humans. 
  • Biomarker analysis at the site of injury show increased expression of inflammation-related markers, whereas analysis of the spinal cord shows neural-related markers that point to microglia activity. 
  • Histological findings consistent with peripheral neuropathy.
  • Positive control data including Aprepitant, the substance P (SP) neurokinin-1 (NK1) antagonist MK-869 that showed efficacy in preclinical rodent models but had efficacy-related translational failure in clinical trials.

 

Join us as we characterize a large animal model of peripheral neuropathic pain that addresses the complexity of chronic neuropathic pain conditions, and can be used as a valuable tool for investigating the shift between inflammation-mediated pain and chronic neuropathic pain.

 

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