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Preclinical EAE Models


Experimental Autoimmune Encephalomyelitis (EAE), Myelin mediated disease models for the study of Multiple Sclerosis

eae-models-whitepaper-2 Experimental Autoimmune Encephalomyelitis (EAE) models are commonly employed for the study of multiple sclerosis therapies, The origin of the model is traced back to the development of the rabies vaccine when it caused encephalomyopathy in a small percentage of people who received the vaccine. It was later determined that the myelin antigens were responsible for triggering an immune response targeting the myelin of the patient.


 Download the whitepaper to learn more:

  • Role of myelin related peptides, mycobacterium tuberculosis and pertussis toxin
  • A comparison of the MBP, PLP and MOG induced EAE models
  • Histological data using both H&E ad LFB staining techniques
  • End-readouts, capabilties and data