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MD Biosciences Blog

Qualitative and Semi-Quantitative Analysis of RNA Expression

Posted by MD Biosciences on Oct 20, 2020 11:30:00 AM

In-Situ Hybridization (ISH) and Immunohistochemistry (IHC) Services

Understanding biomarker expression patterns visually within tissue is crucial to our understanding overall physiology, allowing us to better perceive and diagnose diseased states. Both immunohistochemistry (IHC) and RNA in situ Hybridization (ISH) provide images allowing for assessment of localization and quantification of marker expression, while preserving the tissue integrity. IHC and ISH can be used together to validate data or provide complementary information. 

 

The combination of both technologies can provide unique information. It can identify a secreted protein (like growth factors or cytokines) and its origin, identifying both the original cell and protein within the tissue sample. ISH can also be used for detection and quantification of the RNA target inside the tissue. The simultaneous analysis of RNA and protein expression of the same target genes allows for the identification of potential gene expression regulation mechanisms.

 

MD Biosciences offers fully automated IHC and ISH testing, which can be performed using both brightfield and immunofluorescence staining as singleplex or multiplex assays. In addition, we have the capability to combine IHC/ISH testing, allowing for protein/gene expression comparison simultaneously. With whole slide imaging and hosting capabilities, remote viewing, annotation and downloads are easily accessible. Moreover, we offer pathologist review and/or quantitative AI-powered image analysis.

Additional IHC Services


How can our histology team assist with your research? Contact a scientist to discuss customized options that fit your needs! 

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Topics: Biomarkers, Pathology, ID Markers, clinical research, clinical diagnostics, Biotechnology, Histology, GLP, Artificial Intelligence

From Assay Development to Product Supply For COVID-19, Our Laboratories Are Here to Support

Posted by MD Biosciences on Apr 14, 2020 1:26:14 PM

A message from our laboratories to yours: during these times of economic and personal hardship, we want to extend our sincerest support and hope you are keeping well. 

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Topics: Cytokines, assays, drug development, clinical research, Biotechnology, COVID-19

Pain Studies In Pig: advantages for nerve blocks, local & systemic therapies

Posted by MD Biosciences on Nov 22, 2019 10:36:22 AM

MD Biosciences lab has an exclusive expertise in pain studies in the pig. Our scientists have developed an acute model and a neuropathic model in pigs. Both models include a variety of assays that allows us to record spontaneous changes in behavior as well as stimuli induced withdrawal response and electrophysiology monitoring. (Why electrophysiology?)

 

Contact us today to learn how pig studies can benefit your research programs and enhance results of your studies. 


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Topics: Dermal, Pain, CRO/outsourcing, Neuro/CNS, neuropathic pain, Wound Healing, translational research, Electrophysiology, Behavioral Research, porcine model, Nerve Injury

Weekly Science Blog: 3D Printing Heart Valves, Tackling MS and Cancer Therapy Discoveries

Posted by MD Biosciences on Jul 23, 2019 10:15:34 AM

It's Tuesday, which means MD Biosciences is providing coverage of the latest fascinating and innovative discoveries happening all over the world across a wide variety of disciplinary areas. This week's blog is compiling posts from science journals including ScienceDaily, Phys News, Nature, Nature Genetics, Gen News, Matter and Current Biology. Skim the titles below to catch up on what is happening and follow the links to read more about something that catches your eye!  

 


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Weekly Science Blog: Possible Therapies for Spinal Cord Injuries, Reversal for Inflammatory Diseases and More!

Posted by MD Biosciences on Jul 16, 2019 10:00:00 AM

It's Tuesday, which means MD Biosciences is providing coverage of the latest fascinating and innovative discoveries happening all over the world across a wide variety of disciplinary areas. This week's blog is compiling posts from science journals including ScienceDaily, Stem Cell, Gen News and Molecular Nutrition and Food Research. Skim the titles below to catch up on what is happening and follow the links to read more about something that catches your eye!  

 


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Weekly Science News: Spinal Cord Regeneration, Bacterial Speedometers and Biomarker Discoveries

Posted by MD Biosciences on May 14, 2019 10:41:20 AM

It's Tuesday, which means MD Biosciences is providing coverage of the latest fascinating and innovative discoveries happening all over the world across a wide variety of disciplinary areas. This week's blog is compiling posts from science journals including Gen News, Nature Microbiology, ScienceDailyMarine Biological Laboratory and Nature Microbiology. Skim the titles below to catch up on what is happening and follow the links to read more about something that catches your eye!  


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Weekly Science News: Spinal Cord Regeneration, CRIPSR Advancements and AI Technology

Posted by MD Biosciences on Feb 19, 2019 9:58:42 AM

It's Tuesday, which means MD Biosciences is providing coverage of the latest fascinating and innovative discoveries happening all over the world across a wide variety of disciplinary areas. This week's blog is compiling posts from science journals including Gen News, Nature Communications, Sci News and Nature Biotechnology. Skim the titles below to catch up on what is happening and follow the links to read more about something that catches your eye!  

 

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Weekly Science News: Immune System Discoveries, AI Technology and Neuroscience Advances

Posted by MD Biosciences on Feb 12, 2019 9:33:48 AM

It's Tuesday, which means MD Biosciences is providing coverage of the latest fascinating and innovative discoveries happening all over the world across a wide variety of disciplinary areas. This week's blog is compiling posts from science journals including LinkedIn, Mayo Clinic, ScienceDaily, Nature Communications, The Journal of Immunology and Nature Biotechnology. Skim the titles below to catch up on what is happening and follow the links to read more about something that catches your eye!  

 

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Weekly Science News: 3D Cancer Sponges, Immunotherapy Discoveries and Brain Mapping

Posted by MD Biosciences on Feb 5, 2019 10:18:41 AM

It's Tuesday, which means MD Biosciences is providing coverage of the latest fascinating and innovative discoveries happening all over the world across a wide variety of disciplinary areas. This week's blog is compiling posts from science journals including BBC News, Forbes, Nature Medicine, Neuroscience News, News Medical, and Communications Biology. Skim the titles below to catch up on what is happening and follow the links to read more about something that catches your eye!  

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Weekly Science News: Uncovering Pathogenic Mechanisms of Neurodegenerative Diseases and Discussing Ethics of CRIPSR Babies

Posted by MD Biosciences on Jan 29, 2019 10:00:00 AM

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Topics: Inflammation, Neuro/CNS, cancer/tumor, Biomarkers, Academic Research, Metastatic tumor, Immuno-Oncology, preclinical research, Biotechnology, Neuroscience


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