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MD Biosciences Blog

Qualitative and Semi-Quantitative Analysis of RNA Expression

Posted by MD Biosciences on Oct 20, 2020 11:30:00 AM

In-Situ Hybridization (ISH) and Immunohistochemistry (IHC) Services

Understanding biomarker expression patterns visually within tissue is crucial to our understanding overall physiology, allowing us to better perceive and diagnose diseased states. Both immunohistochemistry (IHC) and RNA in situ Hybridization (ISH) provide images allowing for assessment of localization and quantification of marker expression, while preserving the tissue integrity. IHC and ISH can be used together to validate data or provide complementary information. 

 

The combination of both technologies can provide unique information. It can identify a secreted protein (like growth factors or cytokines) and its origin, identifying both the original cell and protein within the tissue sample. ISH can also be used for detection and quantification of the RNA target inside the tissue. The simultaneous analysis of RNA and protein expression of the same target genes allows for the identification of potential gene expression regulation mechanisms.

 

MD Biosciences offers fully automated IHC and ISH testing, which can be performed using both brightfield and immunofluorescence staining as singleplex or multiplex assays. In addition, we have the capability to combine IHC/ISH testing, allowing for protein/gene expression comparison simultaneously. With whole slide imaging and hosting capabilities, remote viewing, annotation and downloads are easily accessible. Moreover, we offer pathologist review and/or quantitative AI-powered image analysis.

Additional IHC Services


How can our histology team assist with your research? Contact a scientist to discuss customized options that fit your needs! 

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Topics: Biomarkers, Pathology, ID Markers, clinical research, clinical diagnostics, Biotechnology, Histology, GLP, Artificial Intelligence

From Assay Development to Product Supply For COVID-19, Our Laboratories Are Here to Support

Posted by MD Biosciences on Apr 14, 2020 1:26:14 PM

A message from our laboratories to yours: during these times of economic and personal hardship, we want to extend our sincerest support and hope you are keeping well. 

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Topics: Cytokines, assays, drug development, clinical research, Biotechnology, COVID-19

Weekly Science News: Uncovering Pathogenic Mechanisms of Neurodegenerative Diseases and Discussing Ethics of CRIPSR Babies

Posted by MD Biosciences on Jan 29, 2019 10:00:00 AM

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Topics: Inflammation, Neuro/CNS, cancer/tumor, Biomarkers, Academic Research, Metastatic tumor, Immuno-Oncology, preclinical research, Biotechnology, Neuroscience

Weekly Science News: Artificial Intelligence,  Neuroscience Discoveries and Clinical Chemistry Tools

Posted by MD Biosciences on Jan 22, 2019 10:00:00 AM

It's Tuesday, which means MD Biosciences is providing coverage of the latest fascinating and innovative discoveries happening all over the world across a wide variety of disciplinary areas. This week's blog is compiling posts from science journals including Nature Medicine, Nature Genetics, Medical Xpress, PM360, ScienceDaily and Science. Skim the titles below to catch up on what is happening and follow the links to read more about something that catches your eye!  

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Topics: Inflammation, Neuro/CNS, cancer/tumor, Biomarkers, Academic Research, Metastatic tumor, Immuno-Oncology, preclinical research, Biotechnology, Neuroscience

Weekly Science News: Immunotherapy Discoveries and Pacemakers for the Brain

Posted by MD Biosciences on Jan 15, 2019 10:00:00 AM

It's Tuesday and we're back with covering the latest fascinating and innovative discoveries happening all over the world across a wide variety of disciplinary area. This week's blog is providing up-to-date news coverage compiling posts from science journals including Advanced Materials, Cell, EurekAlert, ScienceDaily, Proceedings of the National Academy of Sciences, News Medical and Nature Biomedical Engineering. Skim the titles below to catch up on what is happening and follow the links to read more about something that catches your eye!  

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Topics: Inflammation, Neuro/CNS, cancer/tumor, Biomarkers, Academic Research, Metastatic tumor, Immuno-Oncology, preclinical research, Biotechnology, Neuroscience

Weekly Science News: Neuroscience, Immunology and Biotechnology Trends

Posted by MD Biosciences on Jan 8, 2019 10:56:07 AM

Happy New Year from the team at MD Biosciences! This week's blog is providing up-to-date news coverage compiling posts from science journals including Advanced Materials, Cell Reports, Clinical OMICS, Gen News, Neuroscience News, and Science Advances reporting fascinating and innovative discoveries happening all over the world across a wide variety of disciplinary areas. Skim the titles below to catch up on what is happening and to learn some of the top predicted biotechnology trends for 2019! Follow the links to read more about something that catches your eye!  

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Topics: Neuro/CNS, cancer/tumor, Biomarkers, Academic Research, Immuno-Oncology, Biotechnology, Neuroscience

Weekly Science News: Neuroscience, Molecular Biology & Biotechnology Breakthroughs

Posted by MD Biosciences on Dec 18, 2018 10:21:21 AM

MD Biosciences providing up-to-date news coverage compiling posts from science journals including Gen News, Sci News, ScienceDaily, Stanford Medicine, Nature Communications, & eLife reporting fascinating and innovative discoveries happening all over the world across a wide variety of disciplinary areas. Skim the titles below to catch up on what is happening and to learn what the team at MD Biosciences is reading about. Follow the links to read more about something that catches your eye! 

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Topics: Neuro/CNS, cancer/tumor, Biomarkers, Academic Research, Immuno-Oncology, Biotechnology, Neuroscience

Weekly Science News: Stem Cells, Gene Therapy and Neuroscience Highlights

Posted by MD Biosciences on Dec 11, 2018 10:00:00 AM

MD Biosciences providing up-to-date news coverage compiling posts from science journals including Eurek Alert, Gen News, Sci News, ScienceDaily, Nature Communications, & Proceedings of the National Academy of Sciences reporting fascinating and innovative discoveries happening all over the world across a wide variety of disciplinary areas. Skim the titles below to catch up on what is happening and to learn what the team at MD Biosciences is reading about. Follow the links to read more about something that catches your eye! 

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Topics: Neuro/CNS, cancer/tumor, Biomarkers, Academic Research, Immuno-Oncology, Biotechnology, Neuroscience

Weekly Science News: Wound Healing, Stem Cell Discoveries and Neuroscience Breakthroughs

Posted by MD Biosciences on Dec 4, 2018 10:00:00 AM

MD Biosciences providing up-to-date news coverage compiling posts from science journals including Cell Stem Cell, Gen News, News Scientist, Nature Communications & Business Insider reporting fascinating and innovative discoveries happening all over the world across a wide variety of disciplinary areas. Skim the titles below to catch up on what is happening and to learn what the team at MD Biosciences is reading about. Follow the links to read more about something that catches your eye! 

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Topics: Neuro/CNS, cancer/tumor, Biomarkers, Academic Research, Immuno-Oncology, Biotechnology, Neuroscience

Breaking Science News: Weekly Neuroscience, Oncology and Genetics Highlights

Posted by MD Biosciences on Nov 27, 2018 10:00:00 AM

MD Biosciences providing up-to-date news coverage compiling posts from science journals including Alzheimer's Research and Therapy, Journal of Experimental Medicine, News Scientist, ScienceDaily,  & Sci News reporting fascinating and innovative discoveries happening all over the world across a wide variety of disciplinary areas. Skim the titles below to catch up on what is happening and to learn what the team at MD Biosciences is reading about. Follow the links to read more about something that catches your eye! 

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Topics: Neuro/CNS, cancer/tumor, Biomarkers, Academic Research, Immuno-Oncology, Biotechnology, Neuroscience


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