<img height="1" width="1" style="display:none;" alt="" src="https://dc.ads.linkedin.com/collect/?pid=217082&amp;fmt=gif">

Immunology/Inflammation Laboratory Services

Oxazalone-Induced DTH Model

Dermatological Modeling for Inflammatory and Autoimmune Diseases of the Skin


Oxazalone-Induced Delayed Type Hypersensitivity (DTH) Model

 Our Delayed Type Hypersensitivity (DTH) model evaluates the cell-mediated immune response to repeated exposure of skin to oxazolone. This results in a DTH reaction involving CD4+, CD8+ T cells and macrophages, resulting in local skin inflammation characterized by an increased thickness of the skin. An initial sensitization is followed by a challenge, which sets off a release of cytokines initiating a robust inflammatory response. Below are the assessment types and study data.




  • Ear thickness
  • Circulating or tissue level Biomarker analysis (protein or mRNA)
  • Cell Populations in Spleen/Lymph Node by FACS
  • Histology/IHC
  • PK blood collections


Ear Thickness in the DTH Study

ear thickness in the oxazalone-induced DTH efficacy model

Ear thickness of subjects treated with vehicle or Dexamethasone in the oxazalone-induced DTH model.



  • rat DTH
Request Study Proposal





+41-44-986 2628

Email Us