Metabolic syndrome is increasing in incidence and described as a combination of disturbances including glucose intolerance, central obesity, dyslipedemia and hypertension. Our preclinical laboratories offer Metabolic Disease models that include conditions such as diabetes, renal, obesity and inflammatory bowel disease. Multiple induction methods may be available for each disease. Diabetes models may be induced with streptozotocin, the use of db/db or NOD mice.
Inflammatory Bowel Disease (IBD) Models:
Our laboratories are set for performing specialized studies including altered light/dark cycles, individualized sample collection for biomarker analysis as well as studying various other diseases, such as rheumatoid arthritis on the background of a metabolic disease such as obesity. Biomarker studies may include multiplexed cytokine assays, mRNA or histology and immunohistochemistry.
In addition, our expert staff have the experience and the infrastructure to study the interactions between the microbiome and metabolic diseases, adding a new, important dimension to your drug development studies.
Contact us today to discuss your objectives and how we may be able to reach them!
|New chemical entities||Diabetes||Insulin resistance|
|Plant-based compounds||Acute Kidney Injury||Glucose tolerance|