St Paul, MN, November 11, 2008 – MD Biosciences, a global biotechnology company focused in inflammations & neurology research will showcase its pre-clinical capabilities at the 2008 Neuroscience Conference in Washington, DC, November 15 – 19th, 2008, booth 1825. Capabilities included in the showcase are efficacy disease models within Multiple Sclerosis (MS), Gliosis, Parkinson’s Disease, Nociceptive, Neuropathic, Post-operative and Inflammatory Pain.
Multiple sclerosis is a demyelinating disease of the CNS. Due to the clinical and pathological similarities of EAE and MS, EAE has been used as a model for the study of human demyelinating disease and is characterized by a relapsing-remitting disease course with subsequent progressive disability.
- MBP-induced EAE
- MOG-induced EAE
- PLP-induced EAE.
Gliosis is a proliferation of astrocytes in the central nervous system (CNS) in response to injury which results in scar formation. Astrocytes react to injury by hypertrophy and up-regulation of the glial-fibrillary acidic protein. Gliosis, along with neuronal loss, is a prominent feature of many diseases of the central nervous system.
Parkinon's Disease (PD) is a neurogenerative disorder characterized by reduction in striatial (DA) content caused by the loss of dopaminergenic neurons in the Substantia Nigra part compacta (SNpc) and their proportions to the striatum.
- Acute MPTP
- Chronic MPTP
- 6-OHDA
Pain:
MD Biosciences offers Nociceptive, Neuropathic and Inflammatory Pain models:.
- Tail Flick
- Visceral Pain
- Caspaicin
- Post-operative pain
- Chronic Constriction Injury (CCI, Bennett & Xie)
- Taxol induced Neuropathic Pain
- Spinal Nerve Ligation (Chung)
- STZ Diabetic Neuropathy
- Carrageenan Induced Inflammatory Pain
- Adjuvant (CFA) induced Inflammatory Pain
- Arthritic and Monoarthritic Pain.
About MD Biosciences
MD Biosciences provides products and pre-clinical services for companies engaged in inflammations and neurology research. The company is headquartered in Switzerland and has specialized laboratories located in the United States, United Kingdom, and Israel. A panel of scientific experts provides companies’ in-depth expertise and technologies to tackle problems and provide flexible drug discovery solutions, enabling smarter results faster.
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