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MD Biosciences Blog

IHC Staining Image Gallery Now LIVE: High resolution whole slide image samples from in-house histopathology laboratory

Posted by MD Biosciences on Mar 21, 2019 11:57:33 AM

 MD Biosciences has extensive experience in the application of immunohistochemistry to analysis of markers of interest in tissue. Our validated protocols permit such assessments as lymphocyte analysis, cellular proliferation, cellular activation/differentiation, inflammation, biomarker analysis, and much more.

View high-resolution whole slide image examples of our IHC staining results below!

https://www.mdbhistopath.com/immunohistochemistry-image-gallery-ihc-markers 

 

Don't see a marker you're interested in? We provide custom IHC assay development and validation using either commercially available or Sponsor-provided antibodies, and additionally have in-house antibody development facilities for challenging targets. Contact us to discuss a custom project! 

Contact Us Today!  651-641-1770

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Topics: CRO/outsourcing, Biomarkers, Imaging, Pathology, GLP Histopathology, clinical research, Histology, GLP, In-situ Hybridization, Immunohistochemistry, Tissue Processing

De-Risking Human Clinical Studies: A New Pig Model for Nerve Block Therapies Assessment

Posted by MD Biosciences on Mar 18, 2019 11:42:36 AM

The problem: the rat model is limited in assessing any local treatment (cream, skin injections, patches and nerve blocks). 

The solution: translational models in pigs, prior to clinical stages.

  •  A cutting-edge translational model (technically and scientifically): volume of injection, nerve stimulation, imaging, PK, behavioral changes and skin biomarkers.
  •    By utilizing more translational models in larger species, the success rate of drugs entering clinical phases is dramatically increased.  

Now offering a unique model allowing the differentiation between motor dysfunction and pain block following drug application.

Screenshot 2019-03-13 11.53.29

Unique Model Characteristics

  • Similar to the clinic - ultrasound guide and nerve stimulation dosing
  • The study enables the differentiation between motor dysfunction and pain block following drug administration
  • Various readouts: von Frey-stimulation (primary pain), behavior score, motor function score, open field test, incision score, incision healing (histology) and biomarker analysis in skin

We also offer a wide variety of rodent models and services across therapeutic areas including inflammationpainneurodegenerative disease, wound healing, histologycell-based assays, biomarker analysis and statistical review and more to compliment your studies. We look forward to learning more about your research needs and working together. Call us today: 651-641-1770.

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Topics: neuropathic pain, translational research, porcine model

IHC Staining Image Gallery featuring CD3, T-cell co-receptor in tonsil tissue

Posted by MD Biosciences on Mar 15, 2019 12:20:36 PM

Below is a sample staining that demonstrates anti-CD3 IHC, 2x. CD3 is the T-cell co-receptor and is considered a Pan-T Cell lineage marker. T cells are seen surrounding B Cell Follicles in the below tonsillar tissue, demonstrating rich T-cell zones and interspersed t-cells within follicles. More high IHC quality images available upon request, and pathology review available in house.

Call us today for your histology needs: (651) - 451-1770.

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ValidationSlides_Tonsil_IHC_CD3_PanTCellMarker_2x-1

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Topics: Histology, GLP, Immunohistochemistry

Now Offering Synaptic Imaging Assay For Cognition and Neurodegenerative Disease Research

Posted by MD Biosciences on Mar 5, 2019 11:18:22 AM

 A powerful method for cognition, learning and degenerative disease research

 

MD Biosciences offers a synaptic imaging assay for evaluating the effect of different treatments on synapse formation and identification. This assay allows the estimation of inhibitory/excitatory synapses ratio and synaptic strength, a powerful method advancing cognition, learning and degenerative disease research and treatment options. 

Screenshot 2019-03-05 10.13.19

Unique Readouts:

  • Synaptic Count
  • Synaptic Strength
  • Identification of synapse type (excitatory/inhibitory)

 

Call or contact us today for more information!

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Topics: Neuro/CNS, assays, Neuroscience, Nerve Injury, cognition research