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Neuroscience Laboratory Services

Experimental Autoimmune Encephalomyelitis (EAE)

Multiple Sclerosis & Demyelinating Autoimmune/Neurological Disorders

EAE model for the study of human demyelinating diseases

Due to the clinical and pathological similarities of experimental autoimmune encephalomyelitis (EAE) and Multiple Sclerosis (MS), EAE has been used as a model for the study of human demyelinating disease. Both EAE and MS are characterized by a relapsing-remitting disease course with subsequent progressive disability. EAE is characterized by chronic inflammatory demyelination of the central nervous system (CNS) and involves autoimmune CD4+ Th1 cells. These cells develop in the peripheral lymphoid organ and travel to the CNS causing an immune response. The development of T cells is controlled largely by the expression of various cytokines, as well as cellular adhesion molecules.

Pathology of MS

The pathology of MS starts with the activation and proliferation of T cells in the peripheral lymphoid organs. Matrix Mettalloproteinases (MMPs) and adhesion molecules assist the T cells in crossing the blood brain barrier where the T cell engages antigen-MHC complexes in the CNS causing nerve cell damage.

MD Biosciences is an experienced research partner with strength in designing pharmacology efficacy studies for Multiple Sclerosis (MS) demyelination disorders. If you are looking for other models or readouts, our scientists will be happy to assist you with validating them based on professional literature. Contact a scientist to discuss your model requirements.

 

Experience Readouts Options
Biologics Clinical Score Biomarkers
New Chemical Entity (NCEs) Body Weight Histology
Cell-based therapies   Demyelination
    Immuno-histochemistry
    Pharmacokinetics 

 

We offer electrophysiology recording and analysis services suited for MS/EAE models featuring the DANTEC Keypoint Focus tool.   

For interest in EAE Clinical Batch Release Testing Services, please contact us at info-us@mdbiosciences.com with the subject  title "EAE Batch Release Testing."

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preclinical models of EAE for the study of MS (MOG-EAE, MBP-EAE, PLP-EAE)

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