Peripheral Nerve Injury (PNI) Models of Neuropathic Pain
In the SNL model of peripheral neuropathy, the L5 and L6 spinal nerves are isolated and can either be cut or tightly ligated with surgical silk. Axonal degeneration occurs, with all types of axons being approximately equally affected. Pronounced mechanical Allodynia follows, accompanied by spontaneous pain behaviors, cold Allodynia, which lasts for months with no recovery.In the SNL model, the L4-S2 spinous processes are exposed and part of the L6 transverse process is removed. Tight ligation occurs between L5 and L6. On day 1, inclusion/exclusion is performed based on placement of paw when walking. Two weeks later, pain threshold is tested using Von Frey and continues for length of study.
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Von Frey measurements in the rat SNL (L5) model of peripheral nerve injury