Evaluating neuroprotective therapies for Parkinson's Disease
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We also perform specific staining methods for Parkinson's research, including:
IHC staining using Tyrosine Hydroxylase (TH) antibody - used for staining of Dopaminergic neurons, as TH is one of the enzymes involved in the production of Dopamine in neuronal cells. This staining is used in MPTP-induced PD model in mice or 6-OHDA-induced PD model in rats.
Staining of 6-OHDA-induced Parkinson’s Disease Brain Sections in Rats
Figure A. Subgross image of Substantia Nigra sections showing reduction in number of TH-positive cells in the right hemisphere vs. the left intact hemisphere. Figure B. High magnification of TH-positive dopaminergic neurons. Figure C. Subgross image of TH-positive nerve fibers in section of striatum of the Left intact hemisphere contrasted to the lack of TH staining in the right hemisphere injected with 6-OHDA.