Preclinical Contract Research

Inflammatory Pain

Inflammation/Neurology/Pain

Preclinical Inflammatory Pain Models

Inflammatory pain is best described as pain associated with tissue injury and inflammation, autoimmune disease or exposure to irritating agents. It occurs in response to release of inflammatory mediators from inured tissue that activate and sensitize the nociceptive system.
 
Inflammation, whether acute or chronic, is very often associated with pain. Similar to inflammation, pain can be physiological (an adaptive means of protecting tissues from real or perceived danger) or pathological (chronic, and often debilitating despite resolution of the original stimulus). Chronic pain can be caused by a variety of situations including inflammatory diseases such as some of those listed above (inflammatory pain), tumor formation (cancer pain), and nerve injury (neuropathic pain).
 

 

We offer a range of inflammatory pain models from acute inflammatory pain to chronic pain associated with arthritic conditions. Don't see the model or assessment you are looking for? Our scientists are experienced with validating based on literature. 

 

Experience Range of Readouts Options
Biologics Paw Volume Biomarkers (protein, mRNA)
NCEs Thermal Hyperalgesia Histology/IHC
Plant-based compounds Mechanical Allodynia/VF PK
Analgesics Weight Bearing  
  Motor Function  

 

 Speak to one of our scientists about your requirements.

 

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MIA-induced osteoarthritis preclinical efficacy model

 


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