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MD Biosciences Blog

Brain Mapping and Controversial Gene-Editing: Weekly Science Updates

Posted by MD Biosciences on Oct 16, 2018 10:00:00 AM

MD Biosciences providing up-to-date news coverage compiling posts from science journals including Nature Neuroscience, News: Medical and Life Sciences, Nature, Science Translational Medicine and Sci News reporting fascinating and innovative discoveries happening all over the world across a wide variety of disciplinary areas. Skim the titles below to catch up on what is happening and to learn what the team at MD Biosciences is reading about. Follow the links to read more about something that catches your eye! 

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Topics: Academic Research, Biomarkers, Biotechnology, Neuro/CNS

Weekly Science News: Novel Discoveries in Genome Evolution and Neurodenegerative Diseases

Posted by MD Biosciences on Oct 9, 2018 10:00:00 AM

MD Biosciences providing up-to-date news coverage compiling posts from science journals including Cell Death and Disease, Cell Press, Journal of Craniofacial Surgery, Nature Medicine, ScienceDaily, Science Translational Medicine and Sci News reporting fascinating and innovative discoveries happening all over the world across a wide variety of disciplinary areas. Skim the titles below to catch up on what is happening and to learn what the team at MD Biosciences is reading about. Follow the links to read more about something that catches your eye! 

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Topics: Academic Research, Biomarkers, Biotechnology, Neuro/CNS

Weekly Science News: Gene Discovery and Advancing Cell Regeneration Therapies

Posted by MD Biosciences on Oct 2, 2018 10:00:00 AM

MD Biosciences providing up-to-date news coverage compiling posts from science journals including GigaScience, Nature Communications, Nature Biomedical Engineering, ScienceDaily and Scientific Reports reporting fascinating and innovative discoveries happening all over the world across a wide variety of disciplinary areas. Skim the titles below to catch up on what is happening and to learn what the team at MD Biosciences is reading about. Follow the links to read more about something that catches your eye! 

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Topics: phenotypes, Metastatic tumor, Academic Research, Biomarkers, cancer/tumor, epigenomic

Weekly Highlights: Stem Cells and Biomarkers Paving Advancements in Biotechnology

Posted by MD Biosciences on Sep 25, 2018 10:00:00 AM

MD Biosciences providing up-to-date news coverage compiling posts from science journals including Cell, Cancer Therapy Advisor, Nature Microbiology, Science Translational Medicine, ScienceDaily and Science reporting fascinating and innovative discoveries happening all over the world across a wide variety of disciplinary areas. Skim the titles below to catch up on what is happening and to learn what the team at MD Biosciences is reading about. Follow the links to read more about something that catches your eye! 

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Topics: phenotypes, Metastatic tumor, Academic Research, Biomarkers, cancer/tumor, epigenomic

Genome Sequencing and Immunotherapies: Weekly News

Posted by MD Biosciences on Sep 18, 2018 10:00:00 AM

MD Biosciences providing up-to-date news coverage compiling posts from science journals including Cancer Research, Sci News, Nature GeneticsBritish Journal of Pharmacology and Science reporting fascinating and innovative discoveries happening all over the world across a wide variety of disciplinary areas. Skim the titles below to catch up on what is happening and to learn what the team at MD Biosciences is reading about. Follow the links to read more about something that catches your eye! 

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Topics: Biotechnology, preclinical research, dermatitis, cancer/tumor, Inflammation, Neuro/CNS

Biotechnology Advancements Illuminate Novel Treatments for Human Diseases: Weekly Highlights

Posted by MD Biosciences on Sep 11, 2018 10:00:00 AM

MD Biosciences providing up-to-date news coverage compiling posts from science journals including Health, Nature, Nature Methods and Science reporting fascinating and innovative discoveries happening all over the world across a wide variety of disciplinary areas. Skim the titles below to catch up on what is happening and to learn what the team at MD Biosciences is reading about. Follow the links to read more about something that catches your eye! 

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Topics: Biotechnology, preclinical research, Metastatic tumor

Biomarkers, Drug Discovery and Immunotherapy: Weekly Highlights

Posted by MD Biosciences on Sep 6, 2018 10:00:00 AM

MD Biosciences providing up-to-date news coverage compiling posts from science journals including Nature, Nature Communications and Cell, reporting fascinating and innovative discoveries happening all over the world across a wide variety of disciplinary areas. Skim the titles below to catch up on what is happening and to learn what the team at MD Biosciences is reading about. Follow the links to read more about something that catches your eye! 

                                                                                     image source: wildpixel/Getty Images
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Topics: preclinical research, Discoveries, Life Science, cancer/tumor, Biomarkers

From stem cells to mushrooms: the latest scientific discoveries and technological advances

Posted by MD Biosciences on Aug 28, 2018 9:39:28 AM

MD Biosciences providing up-to-date news coverage compiling posts from science journals and sites including Science Translational Medicine, SciWorthy, ScienceDaily, Science, Gen News, Frontier Pharmacology and American Journal of Pathology, reporting innovative discoveries happening all over the world across a wide variety of disciplinary areas. Skim the titles below to catch up on what is happening and to learn what the team at MD Biosciences is reading about. Follow the links to read more about something that catches your eye! 

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Animal Models of Allergic Asthma: Utilities and Limitations

Posted by MD Biosciences on Aug 16, 2018 10:00:00 AM

Allergic asthma is a chronic inflammatory disease characterized by airway inflammation, changes in structural activity, and bronchial hyperactivity. Scientists have tried to mimic such features of human allergic asthma in murine models as the prevalence of asthma in westernized countries has nearly doubled over the last 20 years to an estimated 180,000 asthma-related deaths per year (WHO, 2018). To date there is no cure for asthma; treatment efforts including inhalers, diet intervention and steroidal injection are designed for symptom relief (Roland et al., 2018). Other initiatives include electronic health recording (EHR) allowing patients to co-manage disease in between office visits. Such interventions and therapies are temporary, aiming to minimize severity of symptoms and number of office visits but they do not always alter underlying pathological mechanisms. Thus, suitable efficacy models are needed. The Ovalbumin (OVA) and House Dust Mite (HDM)-induced models are widely-used models to explore underlying pathogenesis of asthma and MD Biosciences is proud to offer both  models as resources for testing new therapeutics as well as provide additional ex vivo assessment services to better understand therapeutic method of action.

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Topics: preclinical research, asthma, efficacy, Models, Discoveries, Life Science, Biomarkers

IL-33 and T1/ST2 Function in Wound Healing and Inflammatory Responses

Posted by MD Biosciences on Aug 7, 2018 2:19:52 PM

IL-33 is a member of the IL-1 cytokine family with a widely-recognized inflammatory role in a broad range of skin diseases. It functions as a signaling ligand for the T1/ST2 receptor, also known as IL1RL1, T1 and IL-33R (Palmer and Gabav, 2011). Expression of IL-33 occurs in the nucleus of epithelial and endothelial cells and has been labeled as an “alarmin”—an immunological alarm signaled during cellular distress or cellular necrosis in mammals. Interestingly, recent reports indicate distinct species differences between mice, humans and pigs, prompting further comparative studies. In some murine epidermis models, prominent constitutive IL-33 expression was seen in epidermal keratinocytes and was drastically lost in basal keratinocytes during acute inflammatory events, while other studies observed a drastic increase in IL-33 during inflammatory events (Sundes et al., 2015). The loss of IL-33 from keratinocyte nuclei could be due to protein degradation or another release mechanism not yet identified. In contrast to the prominent constitutive IL-33 expression in murine keratinocytes, IL-33 signal was substantially low in human epidermis, demonstrating weak signals in the nuclei of keratinocytes. The classification as an alarmin is suitable for murine models but may not be as accurate for humans and pigs. 

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