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MD Biosciences Blog

Brain Mapping and Controversial Gene-Editing: Weekly Science Updates

Posted by MD Biosciences on Oct 16, 2018 10:00:00 AM

MD Biosciences providing up-to-date news coverage compiling posts from science journals including Nature Neuroscience, News: Medical and Life Sciences, Nature, Science Translational Medicine and Sci News reporting fascinating and innovative discoveries happening all over the world across a wide variety of disciplinary areas. Skim the titles below to catch up on what is happening and to learn what the team at MD Biosciences is reading about. Follow the links to read more about something that catches your eye! 

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Topics: Academic Research, Biomarkers, Biotechnology, Neuro/CNS

Weekly Science News: Novel Discoveries in Genome Evolution and Neurodenegerative Diseases

Posted by MD Biosciences on Oct 9, 2018 10:00:00 AM

MD Biosciences providing up-to-date news coverage compiling posts from science journals including Cell Death and Disease, Cell Press, Journal of Craniofacial Surgery, Nature Medicine, ScienceDaily, Science Translational Medicine and Sci News reporting fascinating and innovative discoveries happening all over the world across a wide variety of disciplinary areas. Skim the titles below to catch up on what is happening and to learn what the team at MD Biosciences is reading about. Follow the links to read more about something that catches your eye! 

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Topics: Academic Research, Biomarkers, Biotechnology, Neuro/CNS

Weekly Science News: Gene Discovery and Advancing Cell Regeneration Therapies

Posted by MD Biosciences on Oct 2, 2018 10:00:00 AM

MD Biosciences providing up-to-date news coverage compiling posts from science journals including GigaScience, Nature Communications, Nature Biomedical Engineering, ScienceDaily and Scientific Reports reporting fascinating and innovative discoveries happening all over the world across a wide variety of disciplinary areas. Skim the titles below to catch up on what is happening and to learn what the team at MD Biosciences is reading about. Follow the links to read more about something that catches your eye! 

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Topics: phenotypes, Metastatic tumor, Academic Research, Biomarkers, cancer/tumor, epigenomic

Weekly Highlights: Stem Cells and Biomarkers Paving Advancements in Biotechnology

Posted by MD Biosciences on Sep 25, 2018 10:00:00 AM

MD Biosciences providing up-to-date news coverage compiling posts from science journals including Cell, Cancer Therapy Advisor, Nature Microbiology, Science Translational Medicine, ScienceDaily and Science reporting fascinating and innovative discoveries happening all over the world across a wide variety of disciplinary areas. Skim the titles below to catch up on what is happening and to learn what the team at MD Biosciences is reading about. Follow the links to read more about something that catches your eye! 

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Topics: phenotypes, Metastatic tumor, Academic Research, Biomarkers, cancer/tumor, epigenomic

Biomarkers, Drug Discovery and Immunotherapy: Weekly Highlights

Posted by MD Biosciences on Sep 6, 2018 10:00:00 AM

MD Biosciences providing up-to-date news coverage compiling posts from science journals including Nature, Nature Communications and Cell, reporting fascinating and innovative discoveries happening all over the world across a wide variety of disciplinary areas. Skim the titles below to catch up on what is happening and to learn what the team at MD Biosciences is reading about. Follow the links to read more about something that catches your eye! 

                                                                                     image source: wildpixel/Getty Images
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Topics: preclinical research, Discoveries, Life Science, cancer/tumor, Biomarkers

Animal Models of Allergic Asthma: Utilities and Limitations

Posted by MD Biosciences on Aug 16, 2018 10:00:00 AM

Allergic asthma is a chronic inflammatory disease characterized by airway inflammation, changes in structural activity, and bronchial hyperactivity. Scientists have tried to mimic such features of human allergic asthma in murine models as the prevalence of asthma in westernized countries has nearly doubled over the last 20 years to an estimated 180,000 asthma-related deaths per year (WHO, 2018). To date there is no cure for asthma; treatment efforts including inhalers, diet intervention and steroidal injection are designed for symptom relief (Roland et al., 2018). Other initiatives include electronic health recording (EHR) allowing patients to co-manage disease in between office visits. Such interventions and therapies are temporary, aiming to minimize severity of symptoms and number of office visits but they do not always alter underlying pathological mechanisms. Thus, suitable efficacy models are needed. The Ovalbumin (OVA) and House Dust Mite (HDM)-induced models are widely-used models to explore underlying pathogenesis of asthma and MD Biosciences is proud to offer both  models as resources for testing new therapeutics as well as provide additional ex vivo assessment services to better understand therapeutic method of action.

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Topics: preclinical research, asthma, efficacy, Models, Discoveries, Life Science, Biomarkers

The Epigenome Has Made Its Debut

Posted by MD Biosciences on Sep 12, 2016 9:20:35 AM

In its 2015 “Year-in-Review”, Science News declared the “Epigenome” has made its “debut”. Why? Because epigenetic alterations; including acetylation, phosphorylation and methylation have been found to be a means by which genes can be regulated post translation.

While not new, numerous clinical studies have recently been published highlighting the important role methylation plays in epigenetic alterations.

Published findings include:

  • Mutations in the DNA methyltransferase 3A gene (DNMT3A) in transgenic mice supports clinical findings of clonal dominance occurring in aging populations.
  • A poor prognosis in acute myeloid leukemia (AML) is associated with DNMT3A mutations.
  • Presence of DNMT3A mutations is associated with poor prognosis in adult T-cell acute lymphoblastic leukemia (T-ALL).
  • Hypomethylation (due to loss of the enzymatic activity in the DNMTAs) and Hypermethylation (specifically in the promoter region) have both been observed in malignances.
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Topics: Biomarkers, assays, epigenomic, methylation

2015 Recap|Clinical Diagnostics & Translational Research

Posted by MD Biosciences on Dec 17, 2015 4:57:36 PM

As we wind down to years end, we at MD Biosciences would like to thank everyone, especially our collaborators, for making this year a success. We have undergone significant growth that we expect to continue throughout the upcoming year.

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Topics: Pain, Inflammation, Neuro/CNS, post-operative pain, cancer/tumor, Microbiome, Biomarkers, CLIA, Neuropathy

Biomarkers Put Precision In Precision Medicine | AMP 2015

Posted by MD Biosciences on Nov 12, 2015 12:58:51 PM

The 2015 annual AMP meeting opened Novemeber 5th in Austin TX, with a presentation by Dr Brian Druker titled “Imatinib as a Paradigm of Targeted Cancer Therapies.”  This year’s recipient of the AMP Award for Excellence in Molecular Diagnostics, Dr Druker highlighted the importance of identifying patients through biomarkers and matching therapies to the patient.  This theme continued through many of the presentations, posters and vendor exhibits the importance of providing physicians actionable results for patient care and therapeutics.  Molecular diagnostics are critical to any discussion on precision or personalized medicine. 

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Topics: cancer/tumor, Microbiome, Biomarkers, Association for Molecular Pathology, Pathology, precision medicine

Targeting Microbiomes & Biomarkers: Inflammation World Congress

Posted by MD Biosciences on Aug 20, 2015 3:30:00 PM


The 12th World Congress on Inflammation wrapped up on Wednesday August 12th after four days packed with cutting edge inflammatory research by key opinions leaders in the field. Presentations hit every aspect of the scientific spectrum from development of pre-clinical models through retrospective studies on new target therapies and everything in between. Highlights of the conference included the Keynote Lecture by Luke O’Neill of Trinity College Dublin, the Symposium “Mechanisms Underlying Microbiome-Mediated Inflammation”, and multiple discussions on identifying and targeting novel biomarkers of inflammatory diseases.

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Topics: Inflammation, metabolic, Preclinical Discovery, Microbiome, Biomarkers, World Congress on Inflammation