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MD Biosciences Blog

Brain Mapping and Controversial Gene-Editing: Weekly Science Updates

Posted by MD Biosciences on Oct 16, 2018 10:00:00 AM

MD Biosciences providing up-to-date news coverage compiling posts from science journals including Nature Neuroscience, News: Medical and Life Sciences, Nature, Science Translational Medicine and Sci News reporting fascinating and innovative discoveries happening all over the world across a wide variety of disciplinary areas. Skim the titles below to catch up on what is happening and to learn what the team at MD Biosciences is reading about. Follow the links to read more about something that catches your eye! 

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Topics: Academic Research, Biomarkers, Biotechnology, Neuro/CNS

Weekly Science News: Novel Discoveries in Genome Evolution and Neurodenegerative Diseases

Posted by MD Biosciences on Oct 9, 2018 10:00:00 AM

MD Biosciences providing up-to-date news coverage compiling posts from science journals including Cell Death and Disease, Cell Press, Journal of Craniofacial Surgery, Nature Medicine, ScienceDaily, Science Translational Medicine and Sci News reporting fascinating and innovative discoveries happening all over the world across a wide variety of disciplinary areas. Skim the titles below to catch up on what is happening and to learn what the team at MD Biosciences is reading about. Follow the links to read more about something that catches your eye! 

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Topics: Academic Research, Biomarkers, Biotechnology, Neuro/CNS

Genome Sequencing and Immunotherapies: Weekly News

Posted by MD Biosciences on Sep 18, 2018 10:00:00 AM

MD Biosciences providing up-to-date news coverage compiling posts from science journals including Cancer Research, Sci News, Nature GeneticsBritish Journal of Pharmacology and Science reporting fascinating and innovative discoveries happening all over the world across a wide variety of disciplinary areas. Skim the titles below to catch up on what is happening and to learn what the team at MD Biosciences is reading about. Follow the links to read more about something that catches your eye! 

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Topics: Biotechnology, preclinical research, dermatitis, cancer/tumor, Inflammation, Neuro/CNS

Pig Model of Post-operative Pain- Analgesic Assessment

Posted by MD Biosciences on Jan 19, 2016 12:02:49 PM

MD Biosciences, in collaboration with PainReform Ltd and Lahav Research Institute, tested two new anesthetic formulations in the recent publication “Prolonged Analgesic Effect of PRF-108 and PRF-110 on Post-operative Pain in Pigs”, on which MD Biosciences’ CSO Sigal Meilin was the principal author. This article demonstrated how the pig POP model could be used to assess the efficacy of new anesthetic test compounds or new formulations. Results indicate that the tested drug formulations showed great promise over current, commercially available anesthetics.


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Topics: Pain, Neuro/CNS, post-operative pain

2015 Recap|Clinical Diagnostics & Translational Research

Posted by MD Biosciences on Dec 17, 2015 4:57:36 PM

As we wind down to years end, we at MD Biosciences would like to thank everyone, especially our collaborators, for making this year a success. We have undergone significant growth that we expect to continue throughout the upcoming year.

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Topics: Pain, Inflammation, Neuro/CNS, post-operative pain, cancer/tumor, Microbiome, Biomarkers, CLIA, Neuropathy

Pain Response in Pigs Mimics Human Pain Behavior

Posted by MD Biosciences on Nov 17, 2015 12:10:56 PM

The pig peripheral neuritis trauma (PNT) model is an important transitional model that bridges the gap between animal research and the clinic. While we discussed how the the pig PNT model shares many morphological and molecular pathology similarities with skin biopsies from human pain conditions in our poster pdf, our chief scientist was the last, principle author in a preceding publication entitled “Peripheral Neuritis Trauma In Pigs: A Neuropathic Pain Model” in the Journal of Pain. In this paper, authors examine this model in terms of how it relates to the human pain response.

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Topics: Pain, Neuro/CNS, Stress, neuropathic pain

Pig Model Validation In Neuropathic Pain-SfN 2015

Posted by MD Biosciences on Oct 30, 2015 3:31:09 PM

Last week, MD Biosciences presented a poster at the Society for Neurosciences 2015 Conference in Chicago. As strong advocates for the use of pig in translational neuropathic pain research, we introduced a new pig proximal peripheral neuritis trauma (PNT) model that shares many similarities in morphological and molecular pathologies with skin biopsies from human pain conditions. This is particularly true in comparisons with patients suffering from persistent area pain conditions such as postherpetic neuralgia (PHN) and complex regional pain syndrome (CRPS) as well as other chronic pain conditions.

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Topics: Pain, Neuro/CNS, Stress, trauma pain, pain biomarkers, CNS imaging, Imaging

Stress, Trauma & Pain- Image Not Imagine The Evidence| Biomarkers

Posted by MD Biosciences on Sep 11, 2015 10:00:00 AM

 The 9th Annual Congress of the European Pain Federation EFIC® was anything but painful as it concluded last week in Vienna with three days of riveting talks. The speakers consisted of expert pain practitioners, scientists, and policy makers who came together with the goal of “translating evidence into practice”.

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Topics: Pain, Neuro/CNS, EFIC 2015, Stress, Imaging, European Pain Federation

Successfully Predict Neuropathic Pain Conditions

Posted by MD Biosciences on Jun 29, 2015 11:21:00 AM

The rodent has historically been used as the dominant model for the study of pain mechanisms and new therapeutics. There are good reasons for this such as the practicalities and ease of use with small animals as well as the scientific value of having a large database of prior research for predictive validity. The rodent models will continue to be the workhorse driving research and drug discovery, however there is a large failure rate of drugs moving into clinical stages, which failure of rodent models to predict the biology of the clinical condition certainly plays a role. The most well known example of this is the NK1 antagonist that exhibited efficacy-related translational failure in the clinic.

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Topics: Neuro/CNS

Increase Validity of Preclinical Pain Research

Posted by MD Biosciences on Jan 20, 2015 11:12:09 AM

If you work in drug discovery and development, you are well aware of the failure rate at clinical trials. Industry estimates are that clinical candidates have a 85-90% chance of failure during clinical trials, the most costly stage of evaluation. A report in Nature Biotechnology 32, 40–51  breaks this success/failure rate down between phases as well as the likelihood of approval from the start of clinical trials. For candidates that are suspended during clinical stages, 83% of these reported efficacy or safety as the reason for suspension. 

This is costly and time consuming for drug developers. So is there a way to increase the predictability from preclinical phases to clinical phases?  We have been evaluating this question for a number of years in our Research Group at MD Biosciences. Animal models used in preclinical development phases are pivotal for understanding mechanisms that contribute to human disease conditions and effective therapies. Rodent models are commonly employed due to their reproducibility and simplicity, however the predictability to the clinic is often times lacking.

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Topics: Pain, Neuro/CNS, in vivo pain models