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MD Biosciences Blog

Genome Sequencing and Immunotherapies: Weekly News

Posted by MD Biosciences on Sep 18, 2018 10:00:00 AM

MD Biosciences providing up-to-date news coverage compiling posts from science journals including Cancer Research, Sci News, Nature GeneticsBritish Journal of Pharmacology and Science reporting fascinating and innovative discoveries happening all over the world across a wide variety of disciplinary areas. Skim the titles below to catch up on what is happening and to learn what the team at MD Biosciences is reading about. Follow the links to read more about something that catches your eye! 

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Topics: Biotechnology, preclinical research, dermatitis, cancer/tumor, Inflammation, Neuro/CNS

Biotechnology Advancements Illuminate Novel Treatments for Human Diseases: Weekly Highlights

Posted by MD Biosciences on Sep 11, 2018 10:00:00 AM

MD Biosciences providing up-to-date news coverage compiling posts from science journals including Health, Nature, Nature Methods and Science reporting fascinating and innovative discoveries happening all over the world across a wide variety of disciplinary areas. Skim the titles below to catch up on what is happening and to learn what the team at MD Biosciences is reading about. Follow the links to read more about something that catches your eye! 

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Topics: Biotechnology, preclinical research, Metastatic tumor

Biomarkers, Drug Discovery and Immunotherapy: Weekly Highlights

Posted by MD Biosciences on Sep 6, 2018 10:00:00 AM

MD Biosciences providing up-to-date news coverage compiling posts from science journals including Nature, Nature Communications and Cell, reporting fascinating and innovative discoveries happening all over the world across a wide variety of disciplinary areas. Skim the titles below to catch up on what is happening and to learn what the team at MD Biosciences is reading about. Follow the links to read more about something that catches your eye! 

                                                                                     image source: wildpixel/Getty Images
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Topics: preclinical research, Discoveries, Life Science, cancer/tumor, Biomarkers

Animal Models of Allergic Asthma: Utilities and Limitations

Posted by MD Biosciences on Aug 16, 2018 10:00:00 AM

Allergic asthma is a chronic inflammatory disease characterized by airway inflammation, changes in structural activity, and bronchial hyperactivity. Scientists have tried to mimic such features of human allergic asthma in murine models as the prevalence of asthma in westernized countries has nearly doubled over the last 20 years to an estimated 180,000 asthma-related deaths per year (WHO, 2018). To date there is no cure for asthma; treatment efforts including inhalers, diet intervention and steroidal injection are designed for symptom relief (Roland et al., 2018). Other initiatives include electronic health recording (EHR) allowing patients to co-manage disease in between office visits. Such interventions and therapies are temporary, aiming to minimize severity of symptoms and number of office visits but they do not always alter underlying pathological mechanisms. Thus, suitable efficacy models are needed. The Ovalbumin (OVA) and House Dust Mite (HDM)-induced models are widely-used models to explore underlying pathogenesis of asthma and MD Biosciences is proud to offer both  models as resources for testing new therapeutics as well as provide additional ex vivo assessment services to better understand therapeutic method of action.

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Topics: preclinical research, asthma, efficacy, Models, Discoveries, Life Science, Biomarkers

Behavioral Research Assessments & Applications: Quantify Cognitive, Emotional, Sensory & Motor Functions

Posted by MD Biosciences on Jul 24, 2018 9:00:00 AM

Neurological diseases often result in a combination of motor and cognitive deficits. Thus, behavioral assessments in conjunction with physiological readouts offer a broader understanding of the basic biological mechanism of disease and cognitive impairment, highly relevant to therapeutic developments. Utilizing rodent and pig models, MD Biosciences offers a variety of behavioral assessment capabilities applicable to (but not limited to) the following subject areas:

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Topics: Behavioral Research, murine model, porcine model, preclinical research

Evidence Mounts for the Role of Inflammation and Immune Dysregulation in Metabolic Liver Disease Related to Obesity

Posted by MD Biosciences on Jul 19, 2018 9:30:00 AM

Over the past couple of decades, nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) have become the number one cause of liver disease in Western countries. Recent data confirm that NAFLD and NASH play an equally important role in the Middle East, Far East, Africa, the Caribbean, and Latin America. The prevalence of NAFLD/NASH continues to increase along with its associated risk factors, including metabolic disorder, obesity, diabetes and hypertension. Therefore, understanding the mechanism of these diseases has become a priority. Recent investigations into the effect of chronic liver inflammation have shed light on the role of both the adaptive and innate immune systems in both NAFLD and NASH. Long suspected to play a part in such metabolic disorders along with nutrition and hormonal imbalances, the immune system has been of great interest to researchers for development of specific drug targets to maximize glucose regulation, minimize inflammatory damage to tissues and prevent the development of fibrosis that can lead to liver failure.

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Topics: fibrosis, preclinical research, murine model, Pathology, metabolic, Inflammation

Fibrotic Disease Focus: Scleroderma

Posted by MD Biosciences on May 17, 2018 11:41:03 AM

 

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Topics: fibrosis, scleroderma, drug development, translational research, preclinical research, disease models