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MD Biosciences Blog

Pain Studies In Pig: advantages for nerve blocks, local & systemic therapies

Posted by MD Biosciences on Nov 22, 2019 10:36:22 AM

MD Biosciences lab has an exclusive expertise in pain studies in the pig. Our scientists have developed an acute model and a neuropathic model in pigs. Both models include a variety of assays that allows us to record spontaneous changes in behavior as well as stimuli induced withdrawal response and electrophysiology monitoring. (Why electrophysiology?)


Contact us today to learn how pig studies can benefit your research programs and enhance results of your studies. 

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Topics: Dermal, Pain, CRO/outsourcing, Neuro/CNS, neuropathic pain, Wound Healing, translational research, Electrophysiology, Behavioral Research, porcine model, Nerve Injury

Preclinical Pig Models for Therapeutic Studies

Posted by MD Biosciences on Nov 7, 2013 11:08:00 AM

Historically, rodent models have been used for the discovery of various biological mechanisms within disease states as well as preclinical development of therapeutics. Unfortunately there are many ways that the biology of rodents fails to accurately predict the clinical conditions of humans - this is particularly the case in pain therapeutics. This can be evidenced by the estimates that as many as 80% of all drug candidates across therapeutic areas fail in the most expensive stages of development - clinical trials. While the failures can be attributed to various reasons such as insufficient efficacy, unacceptable safety profiles or PK properties. With the high cost of developing new therapeutics, there is certainly the need to validate biological and pharmacological findings in models using larger species, which can also address some of the known differences between rodents and human. The pig is one species which may provide more translatable data to the human condition, particularly in therapeutic areas such as cardiovascular, skin or wound healing conditions, metabolic and pain.

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Topics: Dermal, Pain, CRO/outsourcing, Cardiovascular, metabolic

Wisely Choose Preclinical Model: Large vs. Small Species

Posted by MD Biosciences on Jun 8, 2011 9:46:00 AM

Common models for preclinical efficacy often use rodents as they are readily available, cost effective, easy to handle and most familiar to investigators. In choosing a preclinical model, one also needs to consider the anatomical/functional similarity to humans and there are cases where moving onto a larger species is more relevant to the clinic and human condition. Two of those cases are described below:

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Topics: CRO/outsourcing

Case study: 25 Preclinical CAIA studies, 18 months, 1 Out-licensed Compound

Posted by MD Biosciences on Mar 7, 2011 2:14:00 PM

With the number of blockbuster drugs approaching patent expiration and pharma companies struggling to maintain pipeline and portfolios with in-house programs, companies are increasingly turning to licensing, aquisitions and partnerships. Early-stage licensing deals tend to carry more risk for pharma companies in-licensing. To offset this risk, additional data may be required from the pharma partner to confirm any internal research performed by the biotech/out-licensing company.

Mini-case study. MD Biosciences helps a medium-sized biotech company to develop Rheumatoid Arthritis drug for out-licensing in under two years.

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Topics: CRO/outsourcing

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