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MD Biosciences Blog

Why Pigs? MD Biosciences Published in Göttingen Minipigs Magazine

Posted by MD Biosciences on Mar 17, 2020 1:06:14 PM

MD Biosciences lab was featured with Ellegaard offering an exclusive expertise in pain studies. The article discusses our work to develop and validate models in adult pigs, specifically for chronic and acute pain.

 

View Publication Here

 

When do we recommend to work with minipigs?

MD Biosciences pigs studies include domestic pigs and Göttingen minipigs.

The main advantage of the minipig is that it gains weight much slower than the domestic pig. This could be significant when:

  • The study requires working with adult animals
  • When we run models with chronic diseases ( ≥3 months)
  • Tox and ADME studies are run in Göttingen minipigs, which is significant for standardization

 

Pig models at MD Biosciences: 

Post-Operative Pain

Modified Post-Operative Pain

Neuropathic Pain

Wound Healing

 


Ready to learn how your research can accelerate with pig studies? Contact us today! +1 (651) 641-1770 or info-us@mdbiosciences.com 

 

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Topics: Pain, post-operative pain, neuropathic pain, translational, Wound Healing, translational research, Behavioral Research, porcine model, Neuroscience

Novel Data For MBP-Induced EAE Presented at NeuroImmunology Conference

Posted by MD Biosciences on Mar 10, 2020 10:20:22 AM

Due to the clinical and pathological similarities of experimental autoimmune encephalomyelitis (EAE) and Multiple Sclerosis (MS), EAE  is a model for the study of human demyelinating disease. Both EAE and MS are characterized by a relapsing-remitting disease course with subsequent progressive disability. EAE is characterized by chronic inflammatory demyelination of the central nervous system (CNS) and involves autoimmune CD4+ Th1 cells. These cells develop in the peripheral lymphoid organ and travel to the CNS causing an immune response. The development of T cells is controlled largely by the expression of various cytokines, as well as cellular adhesion molecules.

 

This past month in Paris, our scientists presented at the NeuroImmunology Conference, where they shared novel data in the Myelin Basic Protein (MBP) Induced model used to mimic Multiple Sclerosis (MS). This model is a powerful tool for studying disease pathogenesis as well as potential therapeutic interventions. Below find our poster data. 

 

When conducting MS research,  administration of one dose of MPB in a Lewis rat leads to a single relapse that is characterized by hind paw paralysis. This can be characterized histologically, by infiltration of mononuclear cells to the cervical spinal cord and formation of foci. This model is self-limiting and does not show demyelination.

 

 

Screenshot 2020-03-04 13.16.39

 

 

Other MS-EAE Models at MD Biosciences: 

PLP

MBP

MOG


 

Interested to learn about customizable models for neurodegenerative disease research? Contact us today! 

Contact Us!

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Topics: Neuro/CNS, preclinical research, translational research, disease models, Neuroscience, NeuroImmunology

MD Biosciences Runs NeuroScientific Study: Publishes Positive Results in Fight Against Alzheimer's

Posted by MD Biosciences on Aug 5, 2019 9:46:44 AM

View Publication Here

Our team of neuroscience specialists ran a preclinical study with NeuroScientific Biopharmaceuticals in hopes of progressing towards a human trial later in the year for Alzheimer's. Using lead drug candidate EmtinB known to stimulate the reformation of the neuronal network and restore function of damaged nerve cells, the nerve cells were successfully able to communicate again in this study. In fact, EmtinB was able to stimulate regeneration of nerve cells by more than 300% compared to the control. This is significant in affecting synapse loss, a key contributor of cognitive impairment. Together, we are paving the way for successful therapeutic treatment options for Alzheimer's. Learn about our neurodegenerative animal models, behavioral assessments and other neuroscience research services here! 

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Topics: CRO/outsourcing, Neuro/CNS, preclinical research, Behavioral Research, Neuroscience, Nerve Injury, Alzheimer's

MD Biosciences Launches Neuroscience Services Website: featuring neuropathic pain, neurodegenerative disease models and electrophysiology capabilities

Posted by MD Biosciences on Jun 7, 2019 9:20:59 AM

Now live: a website dedicated to MD Biosciences' cutting-edge neurological and CNS research services offered through our Neuroscience Research Laboratories. Our facilities are fitted with state-of-the-art equipment and technologies for preclinical and translational studies, featuring clinically-relevant read outs and endpoints. Specialties include studies of neuropathic, acute and chronic pain and neurodegenerative/neuroinflammatory diseases. Unique pig translational models and electrophysiology capabilities compliment rodent capabilities and accelerate your program towards their next objectives and milestones. Contact our team today! 651-641-1770 or info@mdbiosciences.com 
Visit Neuroscience Services Website

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Topics: Pain, news, Neuro/CNS, in vivo pain models, post-operative pain, Biomarkers, neuropathic pain, Neuropathy, assays, Batch Release Testing, preclinical research, translational research, Electrophysiology, Behavioral Research, porcine model, Neuroscience, Nerve Injury

Now Offering Synaptic Imaging Assay For Cognition and Neurodegenerative Disease Research

Posted by MD Biosciences on Mar 5, 2019 10:18:22 AM

 A powerful method for cognition, learning and degenerative disease research

 

MD Biosciences offers a synaptic imaging assay for evaluating the effect of different treatments on synapse formation and identification. This assay allows the estimation of inhibitory/excitatory synapses ratio and synaptic strength, a powerful method advancing cognition, learning and degenerative disease research and treatment options. 

Screenshot 2019-03-05 10.13.19

Unique Readouts:

  • Synaptic Count
  • Synaptic Strength
  • Identification of synapse type (excitatory/inhibitory)

 

Call or contact us today for more information!

Contact Us!

 

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Topics: Neuro/CNS, assays, Neuroscience, Nerve Injury, cognition research

Senerga Cell-based Assay for Nerve Injury

Posted by MD Biosciences on Feb 19, 2019 10:26:36 AM

 A novel, rapid in-vitro assay for the screening of compound effects                                                              in nerve injury

Neurite outgrowth is the projection and extension of axonal processes from neuronal cell bodies. Through this process, neurons organize themselves into highly-complex functional networks connected synaptically to one another.


Modulation of this neurite outgrowth process (neuritogenesis) has been implicated in a wide range of CNS diseases, including neurodegenerative disorders such as spinal cord injuries, Parkinson’s Disease and Stroke.

 

MD Biosciences has developed a cell-based platform using primary cells extracted from adult rat, to evaluate the effect of tested compounds in the presence of inhibitory factors. The assay’s unique characteristics enable yielding more translatable results, which can serve as a predictive tool of the compounds’ efficacy in older animals and eventually in humans.

MD Biosciences offers an in-vitro assay to evaluate the effect of potential therapeutics on neurite outgrowth and connectivity (synaptic formation) in primary neuronal cell culture. 

image001


                                                                                     Neurite outgrowth after spinal cord injury in adult animal (Day 7)
Unique Screen Characteristics:

  1. Assays on spinal cord and cortex cell culture
  2. Primary neuronal cells extracted from adult animals
  3. Fast turnaround with results available in approximately 7 days
  4. Primary readout:  number of developed cells and the length of neurites in the presence of the tested compound and vehicle

Call or contact us today for our special introductory price of $1900 per compound. 

Contact Us!

 

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Topics: Neuro/CNS, assays, Neuroscience, Nerve Injury