<img height="1" width="1" style="display:none;" alt="" src="https://dc.ads.linkedin.com/collect/?pid=217082&amp;fmt=gif">

MD Biosciences Blog

MD Biosciences Launches Neuroscience Services Website: featuring neuropathic pain, neurodegenerative disease models and electrophysiology capabilities

Posted by MD Biosciences on Jun 7, 2019 9:20:59 AM

Now live: a website dedicated to MD Biosciences' cutting-edge neurological and CNS research services offered through our Neuroscience Research Laboratories. Our facilities are fitted with state-of-the-art equipment and technologies for preclinical and translational studies, featuring clinically-relevant read outs and endpoints. Specialties include studies of neuropathic, acute and chronic pain and neurodegenerative/neuroinflammatory diseases. Unique pig translational models and electrophysiology capabilities compliment rodent capabilities and accelerate your program towards their next objectives and milestones. Contact our team today! 651-641-1770 or info@mdbiosciences.com 
Visit Neuroscience Services Website

Read More

Topics: Pain, news, Neuro/CNS, in vivo pain models, post-operative pain, Biomarkers, neuropathic pain, Neuropathy, assays, Batch Release Testing, preclinical research, translational research, Electrophysiology, Behavioral Research, porcine model, Neuroscience, Nerve Injury

PNT Pig Model: Highly valuable data for translational pain research

Posted by MD Biosciences on Apr 4, 2019 10:00:00 AM

Despite massive investment in research for treatment options, there are not many effective and safe therapeutics for human chronic neuropathic pain (NP) afflictions. Options are limited due to the lack of translatable animal models, especially large animals who have similar physical and metabolic features to humans (Rice et al., 2008, Henze and Urban, 2010, Swindle et al., 2012). MD Biosciences, Inc. has developed a modified unilateral sciatic nerve PNT model in pigs that produces sustained NP behaviors consistent with those observed in human pain patients. The pig PNT model provides highly valuable data for translational pain research. 

                          Read more in our scientists' latest publication here


MD Biosciences translational models can be enhanced with behavioral analysis capabilities, electrophysiology recordings, histology/IHC services and more. Contact us today for more information: info-us@mdbiosciences.com or (651) 641-1770.

Contact Us!

Read More

Topics: Pain, neuropathic pain, translational research, Behavioral Research, porcine model, Histology

De-Risking Human Clinical Studies: A New Pig Model for Nerve Block Therapies Assessment

Posted by MD Biosciences on Mar 18, 2019 10:42:36 AM

The problem: the rat model is limited in assessing any local treatment (cream, skin injections, patches and nerve blocks). 

The solution: translational models in pigs, prior to clinical stages.

  •  A cutting-edge translational model (technically and scientifically): volume of injection, nerve stimulation, imaging, PK, behavioral changes and skin biomarkers.
  •    By utilizing more translational models in larger species, the success rate of drugs entering clinical phases is dramatically increased.  

Now offering a unique model allowing the differentiation between motor dysfunction and pain block following drug application.

Screenshot 2019-03-13 11.53.29

Unique Model Characteristics

  • Similar to the clinic - ultrasound guide and nerve stimulation dosing
  • The study enables the differentiation between motor dysfunction and pain block following drug administration
  • Various readouts: von Frey-stimulation (primary pain), behavior score, motor function score, open field test, incision score, incision healing (histology) and biomarker analysis in skin

We also offer a wide variety of rodent models and services across therapeutic areas including inflammationpainneurodegenerative disease, wound healing, histologycell-based assays, biomarker analysis and statistical review and more to compliment your studies. We look forward to learning more about your research needs and working together. Call us today: 651-641-1770.

Contact Us! 

Read More

Topics: neuropathic pain, translational research, porcine model

New MDB Publication: Pig open field data in the PNT model for neuropathic pain

Posted by MD Biosciences on Oct 12, 2018 10:00:00 AM

We recently published a publication demonstrating the utility of open field testing in combination with behavioral scoring in the pig peripheral neuritis trauma (PNT) model for pain. Combined together and applied in this model, they represent a powerful tool to assess the spontaneous behavior of pigs in response to pain. Rodent models are often used in pain research as they offer valuable data regarding underlying mechanisms contributing to pain, though they are limited in their translatability to human application. A pivotal benefit of using pig models is their increased translatability to the clinic considering the anatomical and physiological similarities pigs share with humans in comparison to rodents. This paper suggests that pig behavioral patterns are similarly translatable. MD Biosciences is proud to be a leader in neurology-related research, offering a variety of pig studies to enhance development in multiple therapeutic areas.
 

 For more information regarding our pig study services, visit our website or contact us!

 

Read More

Topics: Pain, Stress, trauma pain, pain biomarkers, CNS imaging, Academic Researh, preclinical research, translational research, Behavioral Research, porcine model