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MD Biosciences Blog

De-Risking Human Clinical Studies: A New Pig Model for Nerve Block Therapies Assessment

Posted by MD Biosciences

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on Mar 18, 2019 10:42:36 AM

The problem: the rat model is limited in assessing any local treatment (cream, skin injections, patches and nerve blocks). 

The solution: translational models in pigs, prior to clinical stages.

  •  A cutting-edge translational model (technically and scientifically): volume of injection, nerve stimulation, imaging, PK, behavioral changes and skin biomarkers.
  •    By utilizing more translational models in larger species, the success rate of drugs entering clinical phases is dramatically increased.  

Now offering a unique model allowing the differentiation between motor dysfunction and pain block following drug application.

Screenshot 2019-03-13 11.53.29

Unique Model Characteristics

  • Similar to the clinic - ultrasound guide and nerve stimulation dosing
  • The study enables the differentiation between motor dysfunction and pain block following drug administration
  • Various readouts: von Frey-stimulation (primary pain), behavior score, motor function score, open field test, incision score, incision healing (histology) and biomarker analysis in skin

We also offer a wide variety of rodent models and services across therapeutic areas including inflammationpainneurodegenerative disease, wound healing, histologycell-based assays, biomarker analysis and statistical review and more to compliment your studies. We look forward to learning more about your research needs and working together. Call us today: 651-641-1770.

Contact Us! 

Topics: neuropathic pain, translational research, porcine model