MD Biosciences Blog

MD Biosciences to Showcase Preclinical Capabilities at World Pain Congress

Posted by Amy Clausen on Aug 12, 2008 11:25:00 AM


Zurich, Switzerland, August 12, 2008 - MD Biosciences, a global biotechnology company focused in inflammations & neurology research will showcase its pre-clinical capabilities at the 12th World Congress on Pain (IASP) in Glasgow, Scotland, August 17th - 22nd, 2008. Capabilities included in the showcase are efficacy disease models within Nociceptive, Neuropathic, Post-operative and Inflammatory Pain.


Nociceptive Pain is part of a rapid warning relay instructing the motor neurons of the central nervous system to minimize detected physical harm. Disease models include the Tail Flick Model – used to measure the response to noxious stimuli, the Visceral Pain Model – used to measure the effectiveness of analgesic agents, the Caspaicin model – used to evaluate response mediated by the VR1 pathway, and Post-operative pain models for screening the pathophysiology of hyperalgesia.

Neuropathic Pain is produced by damage to the neurons in the peripheral and central nervous systems. Disease models include the Chronic Constriction Injury (CCI, Bennett & Xie) model - involves inflammation around the nerve, the Taxol induced Neuropathic Pain model – causing peripheral nerve ending injury, the Spinal Nerve Ligation (Chung) Model – nerve ligation between L5 & L6, and the STZ Diabetic Neuropathy model – direct destruction of the nerve associated with high levels of glucose.

Inflammatory Pain is associated with tissue damage and the resulting inflammatory response. Disease models include the Carrageenan Induced Inflammatory Pain, Adjuvant (CFA) induced Inflammatory Pain and Arthritic Pain.

Additional models are offered as requested along with end-point readouts such as biomarker analysis, histology, and gene expression analysis. MD Biosciences will also be showcasing its capabilities at additional events this fall including the Inflammations Research Association (IRA) in September and the American College of Rheumatology (ACR) in October.

 

About MD Biosciences
MD Biosciences provides products and pre-clinical services for companies engaged in inflammations and neurology research. The company is headquartered in Switzerland under Morwell Diagnostics and has specialized laboratories located in the United States, United Kingdom, and Israel. A panel of scientific experts provides companies’ in-depth expertise and technologies to tackle problems and provide flexible drug discovery solutions, enabling smarter results faster.

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New Mouse anti-Collagen Type II (anti-CII) ELISAs.

Posted by Amy Clausen on Mar 3, 2008 11:27:00 AM


St Paul, MN March 4, 2008 – MD Biosciences, a global biotechnology company focused in inflammations research, announces the recent launch of its new line of Mouse anti-Collagen Type II (anti-mouse CII) ELISAs. The new Mouse anti-collagen CII ELISAs allow you to measure antibodies generated against the species of collagen used in the induction of arthritis in mice (bovine, human, mouse, rat, chicken, porcine). IgG and two subclasses (IgG2a and IgG2b) are now available as ready-to-use ELISAs that provide fast, accurate and reliable results.

 

The Collagen-induced arthritis (CIA) model is one of the most widely used models for the study of RA. Collagen type II (CII) in adjuvant is used to induce arthritis by triggering autoreactive B cells, which play an important role in the development of arthritis. This B cell response to CII is strictly T cell dependent, where the B cells predominantly switch isotype to IgG.

 

The anti-Type II Collagen ELISAs offer many improvements over other commercially available anti-Collagen Type II ELISAs. The kits come ready to use eliminating any plate coating or blocking as well as eliminates lengthy sample incubations. The assays can be completed in under 3 hours using only 100 uL of sample. Performance characteristics such as precision CVs less than 10%, recovery and linearity averaging at 82% and 102% respectively, and cross-reactivity with other collagen types of less than 0.004% provide reliable, accurate and sensitive assays for the detection mouse Collagen Type II antibodies.

 

The addition of these assays enhances the arthritis products and services currently offered by MD Biosciences. Research products include assays for measuring type II collagen and antibodies, assay for staining type II collagen, induction reagents such as collagen, adjuvant and ArthritoMabÒ antibody cocktail. Pre-clinical services include collagen-induced arthritis (CIA), Antibody induced arthritis (CAIA), Adjuvant Induced Arthritis as well as in vitro disease models providing the researcher a well-rounded approach for using MD Biosciences products in-house as well as outsourcing other areas of their drug discovery platform.

 

 

About MD Biosciences
MD Biosciences provides products and pre-clinical services for companies engaged in inflammations and neurology research. The company is headquartered in Switzerland under Morwell Diagnostics and has specialized laboratories located in Minnesota, Glasgow, and Israel. A panel of scientific experts provides companies’ in-depth expertise and technologies to tackle problems and provide flexible drug discovery solutions, enabling smarter results faster.

 

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The information in this press release should be considered accurate only as of the date of the release. MD Biosciences has no intention of updating and specifically disclaims any duty to update the information in these press releases.

 

 

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Topics: Research Products

MD Biosciences Releases Mouse OVA-IgE ELISA

Posted by Amy Clausen on Aug 3, 2007 11:30:00 AM

MD Biosciences, a global biotechnology company focused in inflammations research, announces the recent launch of its new Mouse OVA-IgE ELISA. The OVA-IgE ELISA offers researchers sensitive, reproducible, accurate and reliable results for the measurement of OVA specific IgE in mouse serum and cell culture supernate samples. The kit is ready-to-use with all necessary reagents and can be completed in under 2.5 hours, requires small sample sizes and measures levels down to 7.8 ng/mL with a sensitivity of less than 3.8 ng/mL.

Ovalbumin is widely used in inducing an allergic response in mouse models of allergic asthma. Through T cell and B cell signalling, IgE production is stimulated and released into the bloodstream where IgE attaches to cells such as mast cells and basophils. These cells are then activated after the IgE is cross-linked with antigen, initiating the allergic cascade.

In addition the Mouse OVA-IgE ELISA, MD Biosciences also offers other reagents such as T1/ST2 antibodies, in vitro assay services and efficacy disease models for the study of allergic asthma.

About MD Biosciences

MD Biosciences provides products and pre-clinical services for companies engaged in inflammations and neurology research. The company is headquartered in Switzerland under Morwell Diagnostics and has specialized laboratories located in Minnesota, Glasgow, and Israel. A panel of scientific experts provides companies’ in-depth expertise and technologies to tackle problems and provide flexible drug discovery solutions, enabling smarter results faster.

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The information in this press release should be considered accurate only as of the date of the release. MD Biosciences has no intention of updating and specifically disclaims any duty to update the information in these press releases.

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Topics: Research Products

High ArthritoMabTM Antibody Cocktail Activity |18-day RA Model Balb/c Mice

Posted by Amy Clausen on Apr 3, 2007 11:33:00 AM

MD Biosciences releases histology results from an 18-day model of arthritis induced using the ArthritoMab(TM) cocktail of arthritogenic antibodies in Balb/c mice. Results show significant histological changes in the joint of the arthritis group as compared to the normal control group after just 18 days, providing researchers valuable data quickly compared to the traditional collagen-induced arthritis (CIA) model, which can take several weeks or more to produce similar histological results.

Results show significant histological changes in the joint of the arthritis group as compared to the normal control group after just 18 days, providing researchers valuable data quickly compared to the traditional collagen-induced arthritis (CIA) model, which can take several weeks or more to produce similar histological results. Figures 1-3 show the effectiveness of the arthritogenic antibodies, with mean histology scores and staining sections indicating the degree of erosion, hyperplasia and infiltration in the joint of the arthritis group as compared to the control group.

 

ArthritoMab histology

 

 

The ArthritoMabTM Arthritogenic Antibody Cocktail is comprised of 4 monoclonal antibodies to collagen type II (CII) that have been chosen for their epitope specificity. An antibody response to certain epitopes is better associated with arthritis than a response to other epitopes. In the CIA model, the antibody response correlated with arthritis was mainly associated with binding to the epitopes C1, J1, and U1. The ArthritoMabTM monoclonal antibodies were selected to bind to the epitopes C1, J1, U1 and D3 - which are spread over the entire CII region (fragments CB8, CB10 and CB11) encouraging better immune complex formation on the cartilage surface for the initiation of arthritis. The antibody-induced arthritis model using the ArthritoMabTM Arthritogenic Antibody cocktail is a rapid alternative the CIA model.

About MD Biosciences
MD Biosciences provides products and pre-clinical services for companies engaged in inflammations and neurology research. The company is headquartered in Switzerland under Morwell Diagnostics and has specialized laboratories located in Minnesota, Glasgow, and Israel. A panel of scientific experts provides companies’ in-depth expertise and technologies to tackle problems and provide flexible drug discovery solutions, enabling smarter results faster.

 

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The information in this press release should be considered accurate only as of the date of the release. MD Biosciences has no intention of updating and specifically disclaims any duty to update the information in these press releases.

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Topics: Inflammation, Research Products

MD Biosciences Releases New - Improved Collagen Type II ELISA

Posted by Amy Clausen on Feb 28, 2007 11:36:00 AM


St Paul, MN, January 9, 2007 - MD Biosciences, a global biotechnology company focused in inflammations research, accounces the launch of its new and improved Collagen Type II (CII) ELISA for the study of collagen metabolism. CII is a triple stranded pro-molecule that is found predomiinantly, but not exclusively, in cartilage. It's promary role is to provide cartilage with tensile strength and elasticity. Autoimmunity to CII is thought to play a role in the pathogenesis of many autoimmune diseases such as rheumatoid arthritis.

This ELISA offers many improvements over other commercially available CII ELISAs such as increased sensitivity, reproducibility, and accuracy for the reliability of results. The ELISA is designed to quantify the amount of collagen type II produced by cells or present in tissue across a variety of species. The ELISA is also highly specific to CII offering no cross-reactivity to other types of collagen providing reliable results.

In addition to performance improvements, user-friendly improvements such as pre-coated microplates and ready-to-use reagents increase the usability and decrease the preparation time allowing researchers to obtain rapid results in less than 5 hours.

About MD Biosciences
MD Biosciences provides products and pre-clinical services to companies engaged in inflammation and neurology research. The company is headquartered in Switzerland under Morwell Diagnostics and has specialized laboratories located in Minnesota, Glasgow, and Israel. A panel of scientific experts provides companies' in-depth expertise and technologies to provide flexible drug discovery solutions, enabling smarter results faster.

 

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Topics: Research Products